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Estrogen Receptor in a Human Cell Line (MCF-7) from Breast Carcinoma

Open AccessPublished:September 10, 1973DOI:https://doi.org/10.1016/S0021-9258(19)43537-0
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      A stable cell line (MCF-7) derived by pleural effusion from a breast cancer patient has been demonstrated to contain significant amounts of 17β-estradiol receptor. This binding protein is specific for 17β-estradiol and has a Kd equal to 2.5 nm, a sedimentation constant of 4.0 S (and 9.2 S), and a mechanism capable of transporting the 17β-estradiol into the nucleus.

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