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ARTICLE| Volume 247, ISSUE 21, P6960-6962, November 1972

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The Generation of Superoxide Radical during the Autoxidation of Hemoglobin

Open AccessPublished:November 01, 1972DOI:https://doi.org/10.1016/S0021-9258(19)44679-6
The Generation of Superoxide Radical during the Autoxidation of Hemoglobin
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      The autoxidation of oxyhemoglobin to methemoglobin, at pH 6.8, causes the co-oxidation of epinephrine to adrenochrome. Part of this co-oxidation was due to a hemoglobincatalyzed peroxidation of epinephrine and could be inhibited by catalase. The remainder of the co-oxidation of epinephrine was inhibited by superoxide dismutase. This indicates that the autoxidation of oxyhemoglobin results in the generation of superoxide radicals.

      REFERENCES

        • Mccord J.M.
        • Fridovich I.
        J. Biol. Chem. 1969; 244: 6049-6055
        • Mccord J.M.
        • Keele Jr., B.B.
        • Fridovich I.
        Proc. Nat. Acad. Sci. U. S. A. 1971; 68: 1024-1027
        • Weiss J.J.
        Nature. 1964; 202: 83-84
        • Viale R.O.
        • Maggiora G.M.
        • Ingraham L.L.
        Nature. 1964; 203: 183-184
        • Weiss J.J.
        Nature. 1964; 203: 183
        • Peisach J.
        • Blumberg W.E.
        • Wittenberg B.A.
        • Wittenberg J.B.
        J. Biol. Chem. 1968; 243: 1871-1880
        • Politzer P.
        Biochim. Biophys. Acta. 1968; 153: 799-803
        • Bryston J.H.
        • King N.K.
        • Looney F.D.
        • Winfield N.E.
        J. Amer. Chem. Soc. 1969; 91: 2775-2779
        • Yang N.L.
        • Oster G.
        J. Amer. Chem. Soc. 1970; 92: 5265-5266
        • Salvati A.M.
        • Ambrogioni M.T.
        • Tentori L.
        Ital. J. Biochem. 1969; 18: 1-18
        • Beauchamp C.O.
        • Fridovich I.
        Anal. Biochem. 1971; 44: 276-287
        • Wright W.D.
        Nature. 1963; 198: 1239-1244
        • Lemberg R.
        • Legge J.W.
        Hematin Compounds and Bile Pigments. Interscience Publishers, Inc., New York1949: 749
        • Green S.
        • Mazur A.
        • Shore E.
        J. Biol. Chem. 1956; 220: 237-255
        • Brooks J.
        Proc. Roy. Soc. London B Biol. Sci. 1935; 118: 560-577
        • Misra H.P.
        • Fridovich I.
        J. Biol. Chem. 1972; 247: 188-192
        • Forman H.J.
        • Fridovich I.
        Science. 1972; 175: 339
        • Misra H.P.
        • Fridovich I.
        J. Biol. Chem. 1971; 246: 6886-6890
        • Misra H.P.
        • Fridovich I.
        J. Biol. Chem. 1972; 247: 3170-3175
        • Trautner E.M.
        • Bradley T.R.
        Aust. J. Sci. Res. 1951; B4: 303-343

      Article info

      Publication history

      Published online: November 01, 1972
      Received: May 22, 1972

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      DOI: https://doi.org/10.1016/S0021-9258(19)44679-6

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      © 1972 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.

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