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The solubilities of amino acids, diglycine, and triglycine have been measured in water and aqueous ethanol as well as dioxane solutions. Free energies of transfer of amino acid side chains and backbone peptide units from water to ethanol and dioxane solutions have been calculated from these data. The results show the similarity between the effects of ethanol and dioxane on the stability of those side chains and peptide units. In particular, the free energies of transfer of hydrophobic side chains to 100% ethanol and dioxane are essentially identical, and have been used to establish a hydrophobicity scale for hydrophobic side chains.
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Publication history
Published online: April 10, 1971
Received:
October 22,
1970
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© 1971 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.
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