Withdrawal: hSos1 contains a new amino-terminal regulatory motif with specific binding affinity for its pleckstrin homology domain.

VOLUME 277 (2002) PAGES 44171–44179

This article has been withdrawn by the authors (although Rocío Jorge could not be reached and Natalia Martínez passed away). The authors have become aware of errors in the preparation of Figs. 2A, 3A, 4A, and 5A, where some lanes appear to be duplicated. The authors state that although replicated experiments performed at the time of the article as well as subsequent data published by other groups (Sondermann, H., Nagar, B., Bar-Sagi, D., and Kuriyan, J. (2005) Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless. Proc. Natl. Acad. Sci. U.S.A. 102, 16632–16637; Yadav, K. K., and Bar-Sagi, D. (2010) Allosteric gating of Son of sevenless activity by the histone domain. Proc. Natl. Acad. Sci. U.S.A. 107, 3436–3440; and Tartaglia, M., Pennacchio, L. A., Zhao, C., Yadav, K. K., Fodale, V., Sarkozy, A., Pandit, B., Oishi, K., Martinelli, S., Schackwitz, W., Ustaszewska, A., Martin, J., Bristow, J., Carta, C., Lepri, F., Neri, C., Vasta, I., Gibson, K., Curry, C. J., Siguero, J. P., Digilio, M. C., Zampino, G., Dallapiccola, B., Bar-Sagi, D., and Gelb, B. D. (2007) Nat. Genet. 39, 75–79) support the results and conclusions presented in this published paper, they consider that the responsible course of action is to withdraw the article in the interests of maintaining the publication standards of the journal. The authors apologize for any inconvenience they may have caused. The paper with the corrected figures can be obtained by contacting the authors.