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Reply to Roudier et al.: HLA-DRB1 polymorphism, anti-citrullinated protein antibodies, and rheumatoid arthritis

  • Yi Tian Ting
    Affiliations
    Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia
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  • Anthony W. Purcell
    Affiliations
    Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia
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  • Hugh H. Reid
    Affiliations
    Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia
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  • Jamie Rossjohn
    Correspondence
    To whom correspondence should be addressed
    Affiliations
    Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia
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Open AccessPublished:May 04, 2018DOI:https://doi.org/10.1074/jbc.RL118.003013
      This is a response to a letter by Roudier et al. (
      • Roudier J.
      • Balandraud N.
      • Auger I.
      HLA-DRB1 polymorphism, anti-citrullinated protein antibodies, and rheumatoid arthritis.
      ).
      While the authors find no fault with the experiments per se reported in Ref.
      • Ting Y.T.
      • Petersen J.
      • Ramarathinam S.H.
      • Scally S.W.
      • Loh K.L.
      • Thomas R.
      • Suri A.
      • Baker D.G.
      • Purcell A.W.
      • Reid H.H.
      • Rossjohn J.
      The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.
      , some differences against the previous reports highlighted by the authors are likely attributable to differing sensitivities and methodologies of the authors' assays, the peptides used, and the lack of structural resolution of their observations.

      References

        • Roudier J.
        • Balandraud N.
        • Auger I.
        HLA-DRB1 polymorphism, anti-citrullinated protein antibodies, and rheumatoid arthritis.
        J. Biol. Chem. 2018; 2937038
        • Ting Y.T.
        • Petersen J.
        • Ramarathinam S.H.
        • Scally S.W.
        • Loh K.L.
        • Thomas R.
        • Suri A.
        • Baker D.G.
        • Purcell A.W.
        • Reid H.H.
        • Rossjohn J.
        The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.
        J. Biol. Chem. 2018; 293 (29317506): 3236-3251