This is a response to a letter by Roudier et al. (
1
).While the authors find no fault with the experiments per se reported in Ref.
2
, some differences against the previous reports highlighted by the authors are likely attributable to differing sensitivities and methodologies of the authors' assays, the peptides used, and the lack of structural resolution of their observations.References
- HLA-DRB1 polymorphism, anti-citrullinated protein antibodies, and rheumatoid arthritis.J. Biol. Chem. 2018; 2937038
- The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.J. Biol. Chem. 2018; 293 (29317506): 3236-3251
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Published online: May 04, 2018
Edited by Peter CresswellFootnotes
The authors declare that they have no conflicts of interest with the contents of this article.
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