Abbreviations:Hsp27 (heat shock protein 27), JDP (J-domain protein), NBD (nucleotide-binding domain), NMR (nuclear magnetic resonance), PPD (peptidyl-prolyl-cis/trans isomerase domain), PPI (protein–protein interaction), PTM (posttranslational modification), RBD (ribosome-binding domain), RNC (ribosome-nascent-chain), SBD (substrate-binding domain), sHsp (small heat shock protein), TF (trigger factor)
Spy: a chaperone surface that guides the folding trajectory
Trigger factor: highly tuned interaction affinities allow a chaperone to assist in the first stages of nascent protein folding
DnaK: preferential contacts with unfolded states allow a client to find its folded structure
Putting it all together: folding mechanisms of three chaperones
HscB: coordinating final client release by coupling the folding process to cofactor installation
- Cai K.
- Frederick R.O.
- Kim J.H.
- Reinen N.M.
- Tonelli M.
- Markley J.L.
Other chaperones: similarities and many differences
- Noddings C.M.
- Wang R.Y.-R.
- Agard D.A.
- Liu Y.
- Elnatan D.
- Sun M.
- Myasnikov A.G.
- Agard D.A.
- Nachman E.
- Wentink A.S.
- Madiona K.
- Bousset L.
- Katsinelos T.
- Allinson K.
- Kampinga H.
- McEwan W.A.
- Jahn T.R.
- Melki R.
- Mogk A.
- Bukau B.
- Nussbaum-Krammer C.
- Mok S.-A.
- Condello C.
- Freilich R.
- Gillies A.
- Arhar T.
- Oroz J.
- Kadavath H.
- Julien O.
- Assimon V.A.
- Rauch J.N.
- Dunyak B.M.
- Lee J.
- Tsai F.T.F.
- Wilson M.R.
- Zweckstetter M.
- et al.
Conflict of interest
Funding and additional information
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Present address for Taylor Arhar: Department of Chemistry, Beloit College, Beloit WI, USA.
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