Virtual Issue: Cancer

Virtual Issue: Cancer

Between 2010 and 2020, the number of new cancer cases is expected to increase by approximately 1.8 million per year in the USA alone, according to predictions by the Center for Disease Control. During this period, enormous strides have been made in our understanding of the basic mechanisms that govern cancer initiation and progression. This virtual issue highlights a number of primary research papers from the last three years with a focus on discoveries on the mechanistic basis of cancer cell signaling, reprogramming of tumor metabolism, cancer genetics and the tumor microenvironment, and the development and characterization of drugs for cancer treatment. We hope you enjoy this collection.

The cover art shows a fluorescence micrograph of lysyl hydroxylase 2, previously shown to enhance the metastatic propensity of lung cancer by creating collagen crosslinks, co-localized with extracellular collagen in human lung adenocarcinoma, as reported by Chen et al. Cover design by Lisa Schnabel.

Assembled by Alex Toker; published December 2019

Find more virtual issues

Tumor metabolism

Cancer cell signaling

Cancer genetics

Therapeutics and mechanisms of drug action

Cancer biology