Virtual Issue: Drug metabolism, transport and toxicity
JBC published the first reports on cytochrome P450 enzymes involvement in drug metabolism by Omura and Sato, opening up a whole new area of investigation for eager biological chemists. Critical reports on glutathione metabolism and glutathione transferase – the enzymes that catalyze drug conjugations—followed, and JBC has continued to take an active interest in research in the field of drug metabolism, commonly discussed by its better-known acronym “ADME”. To honor this field, and particularly the combined 22nd Symposium on Microsomes and Drug Oxidation/33rd Japanese Society for the Study of Xenobiotics in Kanazawa, Japan, 1-5 October 2018, we’ve assembled a collection of papers published in recent years from the field at large as well as some of the speakers at the meeting. While the author versions of the papers are always freely available, as with all JBC content, the redacted versions of these articles are also free through the end of October 2018. The topics featured at the Symposium on Microsomes and Drug Oxidation has certainly changed since the first meeting held in Bethesda, Maryland in 1968: Some aspects, e.g. gene regulation, were in their infancy 50 years ago and some areas such as drug transporters were unknown. We are excited to see the ongoing growth in the field, and look forward to another 50 years of fantastic science. I hope that you will enjoy reading papers in this Virtual Issue and we look forward to seeing yours in JBC as well!
The cover art shows how cytochrome P450 4B1 orients its ligand to catalyze a disfavored regiospecific reaction, as reported by Hsu et al and depicted here by Emily Scott. Artwork created by Valery Masterson.
Assembled by F. Peter Guengerich; published September 2018