Editors’ Picks, formerly called Papers of the Week, represent the top-rated papers published in JBC across the field of biological chemistry, as determined by our Associate Editors, Editorial Board Members and other referees. These articles—essential for any reading list—are accompanied by additional content summarizing the new findings and featuring the scientists involved.
- Editors' PicksSoluble guanylyl cyclase (sGC) is the main receptor for nitric oxide (NO) and a central component of the NO-cGMP pathway, critical to cardiovascular function. NO binding to the N-terminal sensor domain in sGC enhances the cyclase activity of the C-terminal catalytic domain. Our understanding of the structural elements regulating this signaling cascade is limited, hindering structure-based drug design efforts that target sGC to improve the management of cardiovascular diseases. Conformational changes are thought to propagate the NO-binding signal throughout the entire sGC heterodimer, via its coiled-coil domain, to reorient the catalytic domain into an active conformation.