Virtual Issue: Genome editing

Genome editing

Molecular biology techniques have made it possible to generate genetic variants for decades, but the incorporation of zinc finger nucleases, TALENs and of course CRISPR/Cas into this toolbox have drastically altered the face of modern scientific research. The editors at JBC are proud to support the biological chemistry community’s advances in genome editing methodologies, whether making existing techniques more expedient and trackable or extending to new organisms that have previously been genetically intractable. Similarly, we appreciate the new insights gained into how these systems work and continue to be amazed at how these techniques are enabling new investigations. To honor this field, we’ve assembled a collection of research papers published in 2016-2018 that showcase new methods, mechanisms and applications. While the author versions of the papers are always freely available, as with all JBC content, the redacted versions of these articles are also free through the end of September 2018. We hope this you enjoy this collection and thank all the authors who have contributed to JBC.

The cover art shows the genetic edits made to retinitis pigmentosa 2, mutations of which cause retinal degeneration, and the resultant loss of protein signal, as reported by Liu et al. Artwork created by Valery Masterson.

Assembled by Joel Gottesfeld and Catherine Goodman; published September 2018

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