Virtual Issue: Signaling through space and time

Virtual Issue: Signaling through space and time

G protein-mediated signaling influences all aspects of cellular communication, and our understanding of the importance of these pathways continues to grow as we identify the biomolecules involved and the extent to which G protein networks control diverse biological processes across disparate cellular locations and with various temporal behaviors. This virtual issue is correspondingly organized into three themes, focused on key signaling proteins and their actions in space and time.

The creation of this Virtual Issue, capturing JBC papers published in the last 3 years, was motivated by the 2018 Gordon Research Conference, “Phosphorylation and G-Protein Mediated Signaling Networks”, held June 3-8. As a result, each theme highlights one or two “Editors’ Pick” (formerly “Paper of the Week”) articles, with the remaining papers featuring scientists who are current or recent speakers at the meeting. The author versions of these papers are freely available, as with all JBC content, and the redacted forms have been made free through mid-June.

Like JBC, this conference has a distinguished history, dating back to its inauguration in 1970. Indeed, nearly all of the previous conference organizers have served on the JBC Editorial Board. The 1970 conference was organized by researchers who first discovered cAMP second messengers (Alan Robison and Nobel Laureate Earl Sutherland). Subsequent meetings were chaired by scientists (and other future Nobelists!) who pioneered the study of cGMP (Ferid Murad), G proteins (Alfred Gilman and Martin Rodbell) and protein kinases (Edwin Krebs). Many of these scientists published their landmark findings in JBC, and these have been highlighted as journal “Classics” (see links).

JBC has a long tradition of publishing in the areas of phosphorylation and G-protein mediated signaling. Looking forward, we hope to sustain the tradition by considering new findings presented at this and other conferences in the future.

The cover art shows the inactive form of the human glucagon receptor, as reported by Yin et al. Artwork created by Valery Masterson.

Assembled by Henrik Dohlman; published May 2018

Find more virtual issues

Signaling proteins


Signaling in space


Signal modulation over time


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