Virtual Issue: Immunometabolism

Virtual Issue: Immunometabolism

Immunometabolism has emerged as a very exciting area of research in immunology. The number of papers published since 2010 has skyrocketed as immunologists dust off their old biochemistry text books and re-learn the wonders of glycolysis, the TCA cycle, the pentose phosphate pathway and the intricacies of amino acid metabolism. But this isn’t just about how different immune cell types use different metabolic processes for energy, anabolism or catabolism. It’s also about signaling. Metabolites are used to modulate signaling pathways and also regulate enzymes that modify histones and DNA to have an epigenetic impact. Mitochondrial alterations have also become a focus with disturbance leading to inflammatory cell activation. In this virtual issue we have gathered together fascinating papers recently published in this area in JBC, a fitting journal which published most of the landmark papers in metabolism in the 20th century. The redacted versions of these papers have also been made freely available. We look forward to receiving more discoveries in this boundless area which is leading to a whole new level of understanding in immunoregulation.

The cover art depicts immunometabolic consequences of infection by Mycobacterium leprae, including down-regulation of mitochondrial activity and reduced lactate production. The resultant modulation of host cell glucose metabolism facilitates persistence of infection. These findings reported by Medeiros et al. provide new insights into neuropathy in leprosy. Artwork created by EJ Marklin.

Assembled by Luke O’Neill; published March 2019

Find more virtual issues

A primer on immunometabolism

Epigenetics and differentiation

Innate immunity