Advertisement

December 7, 2022

Calmodulin variant E140G associated with long QT syndrome impairs CaMKIIδ autophosphorylation and L-type calcium channel (Cav1.2) inactivation

  • Ohm Prakash,
  • Nitika Gupta,
  • Amy Milburn,
  • ...
  • Svetlana Antonyuk,
  • Caroline Dart,
  • Nordine Helassa
Published online: December 07, 2022
102777

Oxidative stress in the mitochondrial matrix underlies ischemia/reperfusion-induced mitochondrial instability

  • Soroosh Solhjoo,
  • Ting Liu,
  • Agnieszka Sidor,
  • Dong I. Lee,
  • Brian O’Rourke,
  • Charles Steenbergen
Published online: December 07, 2022
102780

Surface electrostatics dictate RNA-binding protein CAPRIN1 condensate concentration and hydrodynamic properties

  • Yuki Toyama,
  • Atul Kaushik Rangadurai,
  • Julie D. Forman-Kay,
  • Lewis E. Kay
Published online: December 07, 2022
102776

December 6, 2022

A splicing-dependent ER retention signal regulates surface expression of the mechanosensitive TMEM63B cation channel

  • Dan Wu,
  • Lushan Xu,
  • Wen-Min Cai,
  • ...
  • Guoqiang Wan,
  • Yun Xu,
  • Yun Stone Shi
Published online: December 06, 2022
102781

December 5, 2022

Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate

  • Viacheslav Kriachkov,
  • Angelique R. Ormsby,
  • Eric P. Kusnadi,
  • ...
  • Matthew E. Ritchie,
  • Luc Furic,
  • Danny M. Hatters
Published online: December 05, 2022
102774

December 3, 2022

A mid-position NOTCH3 truncation in inherited cerebral small vessel disease may affect the protein interactome

  • Soo Jung Lee,
  • Xiaojie Zhang,
  • Gang Xu,
  • Jimo Borjigin,
  • Michael M. Wang
Published online: December 03, 2022
102772

Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth

  • David J. Wisniewski,
  • Mariya S. Liyasova,
  • Soumya Korrapati,
  • ...
  • Natalie Porat-Shliom,
  • Christina M. Annunziata,
  • Stanley Lipkowitz
Published online: December 03, 2022
102766

December 2, 2022

Mapping the KRAS Proteoform Landscape in Colorectal Cancer Identifies Truncated KRAS4B that Decreases MAPK Signaling

  • Lauren M. Adams,
  • Caroline J. DeHart,
  • Bryon S. Drown,
  • ...
  • Michael Caldwell,
  • Reza Vafabakhsh,
  • Neil L. Kelleher
Published online: December 02, 2022
102768

DNA repair protein RAD52 is required for protecting G-quadruplexes in mammalian cells

  • Shuo Liu,
  • Zi Wang,
  • Sameer Bikram Shah,
  • ...
  • Tran Nguyen,
  • Rong Xiang,
  • Xiaohua Wu
Published online: December 02, 2022
102770

Identification, binding, and structural characterization of single domain anti-PD-L1 antibodies inhibitory of immune regulatory proteins PD-1 and CD80

  • Tara Kang-Pettinger,
  • Kayleigh Walker,
  • Richard Brown,
  • ...
  • Peter J. Coombs,
  • Mark D. Carr,
  • Gareth Hall
Published online: December 02, 2022
102769

Phosphorylation-dependent interactions of myosin binding protein-C and troponin coordinate the myofilament response to Protein Kinase A

  • Ivanka R. Sevrieva,
  • Saraswathi Ponnam,
  • Ziqian Yan,
  • Malcolm Irving,
  • Thomas Kampourakis,
  • Yin-Biao Sun
Published online: December 02, 2022
102767

Free fatty acids stabilize integrin β1 via S-nitrosylation to promote monocyte-endothelial adhesion

  • Qinyu Yao,
  • Qi Cui,
  • Jia Liu,
  • ...
  • Baochang Lai,
  • Lei Xiao,
  • Nanping Wang
Published online: December 02, 2022
102765

December 1, 2022

Molecular basis for the recruitment of the Rab effector protein WDR44 by the GTPase Rab11

  • Matthew C. Thibodeau,
  • Noah J. Harris,
  • Meredith L. Jenkins,
  • ...
  • Daniel Pokorný,
  • Thomas A. Leonard,
  • John E. Burke
Published online: December 01, 2022
102764

Neutron crystallography and quantum chemical analysis of bilin reductase PcyA mutants reveal substrate and catalytic residue protonation states

  • Tatsuya Joutsuka,
  • Ryota Nanasawa,
  • Keisuke Igarashi,
  • ...
  • Andreas Ostermann,
  • Katsuhiro Kusaka,
  • Masaki Unno
Published online: December 01, 2022
102763

The structure of caseinolytic protease subunit ClpP2 reveals a functional model of the caseinolytic protease system from Chlamydia trachomatis

  • Jahaun Azadmanesh,
  • Mohamed A. Seleem,
  • Lucas Struble,
  • ...
  • Gloria E.O. Borgstahl,
  • Scot P. Ouellette,
  • Martin Conda-Sheridan
Published online: December 01, 2022
102762

The crystal structure of the EspB-EspK virulence factor-chaperone complex suggests an additional type VII secretion mechanism in M. tuberculosis

  • Abril Gijsbers,
  • Mathias Eymery,
  • Ye Gao,
  • ...
  • Peter J. Peters,
  • Andrew McCarthy,
  • Raimond B.G. Ravelli
Published online: December 01, 2022
102761

November 30, 2022

Temperature instability of a mutation at a multi-domain junction in Na,K-ATPase isoform ATP1A3 (p.Arg756His) produces a fever-induced neurological syndrome

  • Elena Arystarkhova,
  • Mads S. Toustrup-Jensen,
  • Rikke Holm,
  • ...
  • Allison Brashear,
  • Bente Vilsen,
  • Kathleen J. Sweadner
Published online: November 30, 2022
102758

November 29, 2022

Off the deep end: what can deep learning do for the gene expression field?

  • Ana-Maria Raicu,
  • Justin C. Fay,
  • Nicolas Rohner,
  • Julia Zeitlinger,
  • David N. Arnosti
Published online: November 29, 2022
102760

Rapid Excision of Oxidized Adenine by Human Thymine DNA Glycosylase

  • Hardler W. Servius,
  • Lakshmi S. Pidugu,
  • Matthew E. Sherman,
  • Alexander C. Drohat
Published online: November 29, 2022
102756

The AF-2 cofactor binding region is key for the selective SUMOylation of estrogen receptor alpha by antiestrogens

  • Amandine Vallet,
  • Mohamed El Ezzy,
  • Marine Diennet,
  • Salwa Haidar,
  • Michel Bouvier,
  • Sylvie Mader
Published online: November 29, 2022
102757

November 28, 2022

Archaeal tRNA meets biotechnology: From vaccines to genetic code expansion

  • Lluís Ribas de Pouplana
Published online: November 28, 2022
102755

November 25, 2022

The permanently chaperone-active small heat shock protein Hsp17 from C. elegans exhibits topological separation of its N-terminal regions

  • Annika Strauch,
  • Benjamin Rossa,
  • Fabian Köhler,
  • ...
  • Martin Haslbeck,
  • Sevil Weinkauf,
  • Johannes Buchner
Published online: November 25, 2022
102753

November 24, 2022

S-Acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction

  • Liam Butler,
  • Carolina Locatelli,
  • Despoina Allagioti,
  • ...
  • Nicholas C.O. Tomkinson,
  • Christine Salaun,
  • Luke H. Chamberlain
Published online: November 24, 2022
102754

Lack of ApoE inhibits ADan amyloidosis in a mouse model of Familial Danish Dementia

  • Anllely Fernandez,
  • Maria-Teresa Gomez,
  • Ruben Vidal
Published online: November 24, 2022
102751

Determinants of receptor tyrosine phosphatase homophilic adhesion: structural comparison of PTPRK and PTPRM extracellular domains

  • Iain M. Hay,
  • Maria Shamin,
  • Eve R. Caroe,
  • ...
  • Stephen C. Graham,
  • Hayley J. Sharpe,
  • Janet E. Deane
Published online: November 24, 2022
102750

An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses

  • Joe McKellar,
  • Mary Arnaud-Arnould,
  • Laurent Chaloin,
  • ...
  • Mickaël Blaise,
  • Olivier Moncorgé,
  • Caroline Goujon
Published online: November 24, 2022
102747

November 23, 2022

Next-generation retinoid X receptor agonists increase ATRA signaling in organotypic epithelium cultures and have distinct effects on receptor dynamics

  • Nathalia Melo,
  • Olga V. Belyaeva,
  • Wilhelm K. Berger,
  • ...
  • Laszlo Nagy,
  • Natalia Y. Kedishvili,
  • Matthew B. Renfrow
Published online: November 23, 2022
102746

NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet

  • Schuyler D. Vickers,
  • Stephanie A. Shumar,
  • Dominique C. Saporito,
  • ...
  • Aniello M. Infante,
  • John M. Hollander,
  • Roberta Leonardi
Published online: November 23, 2022
102745

Seawater fish use an electrogenic boric acid transporter, Slc4a11A, for boric acid excretion by the kidney

  • Akira Kato,
  • Yuuri Kimura,
  • Yukihiro Kurita,
  • ...
  • Hiroyuki Doi,
  • Shigehisa Hirose,
  • Michael F. Romero
Published online: November 23, 2022
102740

IFITM proteins: understanding their diverse roles in viral infection, cancer, and immunity

  • Maria Gómez-Herranz,
  • Jordan Taylor,
  • Richard D. Sloan
Published online: November 23, 2022
102741

Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway

  • Derek A. Franklin,
  • Shijie Liu,
  • Aiwen Jin,
  • ...
  • Gang Greg Wang,
  • Yisong Y. Wan,
  • Yanping Zhang
Published online: November 23, 2022
102739

November 21, 2022

GLUT1 is a Highly Efficient L-Fucose Transporter

  • Bobby G. Ng,
  • Paulina Sosicka,
  • Zhijie Xia,
  • Hudson H. Freeze
Published online: November 21, 2022
102738

Nanobody derived using a peptide epitope from the Spike protein receptor-binding motif inhibits entry of SARS-CoV-2 variants

  • Nivya Mendon,
  • Rayees Ganie,
  • Shubham Kesarwani,
  • ...
  • Prakash Lama,
  • Anchal Chandra,
  • Minhajuddin Sirajuddin
Published online: November 21, 2022
102732

Rate of transcription elongation and sequence-specific pausing by RNA polymerase I directly influence ribosomal RNA processing

  • Abigail K. Huffines,
  • Krysta L. Engel,
  • Sarah L. French,
  • Yinfeng Zhang,
  • Olga V. Viktorovskaya,
  • David A. Schneider
Published online: November 21, 2022
102730

BY-kinases: protein tyrosine kinases like no other

  • Fatlum Hajredini,
  • Sébastien Alphonse,
  • Ranajeet Ghose
Published online: November 21, 2022
102737

Obtaining the necessary molybdenum cofactor for sulfite oxidase activity in the nematode C. elegans surprisingly involves a dietary source

  • Kevin D. Oliphant,
  • Robin R. Fettig,
  • Jennifer Snoozy,
  • Ralf R. Mendel,
  • Kurt Warnhoff
Published online: November 21, 2022
102736

SOX9 and TCF transcription factors associate to mediate Wnt/β-catenin target gene activation in colorectal cancer

  • Aravinda-Bharathi Ramakrishnan,
  • Peter E. Burby,
  • Kavya Adiga,
  • Ken M. Cadigan
Published online: November 21, 2022
102735

Hydroxylation site-specific and production-dependent effects of endogenous oxysterols on cholesterol homeostasis: Implications for SREBP-2 and LXR

  • Hodaka Saito,
  • Wakana Tachiura,
  • Mizuki Nishimura,
  • Makoto Shimizu,
  • Ryuichiro Sato,
  • Yoshio Yamauchi
Published online: November 21, 2022
102733

Zinc dynamics regulate early ovarian follicle development

  • Yu-Ying Chen,
  • Si Chen,
  • Kiwon Ok,
  • Francesca E. Duncan,
  • Thomas V. O’Halloran,
  • Teresa K. Woodruff
Published online: November 21, 2022
102731

November 18, 2022

Biphasic transcriptional and post-transcriptional regulation of MYB by androgen signaling mediates its growth control in prostate cancer

  • Srijan Acharya,
  • Shashi Anand,
  • Mohammad Aslam Khan,
  • ...
  • Sanjeev Kumar Srivastava,
  • Seema Singh,
  • Ajay Pratap Singh
Published online: November 18, 2022
102725

Systematic pharmacological analysis of agonistic and antagonistic fibroblast growth factor receptor 1 MAbs reveals a similar unique mode of action

  • Jocelyn Chan,
  • Joyce Chan,
  • Lily Shao,
  • ...
  • James T. Koerber,
  • Gabriele Schaefer,
  • Laetitia Comps-Agrar
Published online: November 18, 2022
102729

Exploration of the cysteine reactivity of human inducible Hsp70 and cognate Hsc70

  • Zhouping Hong,
  • Weibin Gong,
  • Jie Yang,
  • ...
  • Zhenyan Liu,
  • Sarah Perrett,
  • Hong Zhang
Published online: November 18, 2022
102723

rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice

  • Hao-Cheng Chang,
  • Yu-Ju Lee,
  • Sehrish Javed,
  • ...
  • Yu Cheng Lin,
  • Cameron Oram,
  • Wei-Hsiang Huang
Published online: November 18, 2022
102728

Yeast 9-1-1 complex acts as a sliding clamp for DNA synthesis by DNA polymerase ε

  • Narottam Acharya,
  • Louise Prakash,
  • Satya Prakash
Published online: November 18, 2022
102727

Impact of inherent biases built into proteomic techniques: Proximity labeling and affinity capture compared

  • Claudia Maria do Nascimento Moreira,
  • Cristina D. Kelemen,
  • Samson O. Obado,
  • ...
  • Mark C. Field,
  • Susanne Kramer,
  • Martin Zoltner
Published online: November 18, 2022
102726

A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling

  • Taiga Maemoto,
  • Yuichi Kitai,
  • Runa Takahashi,
  • ...
  • Toyoyuki Ose,
  • Kenji Oritani,
  • Tadashi Matsuda
Published online: November 18, 2022
102724

Products of the visual cycle are detected in mice lacking retinol binding protein 4, the only known vitamin A carrier in plasma

  • Diego Montenegro,
  • Jin Zhao,
  • Hye Jin Kim,
  • Igor O. Shmarakov,
  • William S. Blaner,
  • Janet R. Sparrow
Published online: November 18, 2022
102722

November 17, 2022

Activin receptor ALK4 promotes adipose tissue hyperplasia by suppressing differentiation of adipocyte precursors

  • Ee-Soo Lee,
  • Tingqing Guo,
  • Raj Kamal Srivastava,
  • Assim Shabbir,
  • Carlos F. Ibáñez
Published online: November 17, 2022
102716

Lysyl hydroxylase 3 mediated post-translational modifications are required for proper biosynthesis of collagen α1α1α2(IV)

  • Yoshihiro Ishikawa,
  • Yuki Taga,
  • Thibault Coste,
  • ...
  • Kazunori Mizuno,
  • Elisabeth Tournier-Lasserve,
  • Douglas B. Gould
Published online: November 17, 2022
102713

November 16, 2022

Quantitative affinity measurement of small molecule ligand binding to Major Histocompatibility Complex class-I related protein 1 MR1

  • Carl J.H. Wang,
  • Wael Awad,
  • Ligong Liu,
  • ...
  • David P. Fairlie,
  • Jamie Rossjohn,
  • Jérôme Le Nours
Published online: November 16, 2022
102714

Glucagon Changes Substrate Preference in Gluconeogenesis

  • Huiting Xu,
  • Yujue Wang,
  • Hyokjoon Kwon,
  • ...
  • Xiaoyang Su,
  • Ling He,
  • Fredric E. Wondisford
Published online: November 16, 2022
102708

November 15, 2022

A cell-based bioluminescence reporter assay of human Sonic Hedgehog protein autoprocessing to identify inhibitors and activators

  • Daniel A. Ciulla,
  • Patricia Dranchak,
  • John L. Pezzullo,
  • ...
  • José-Luis Giner,
  • James Inglese,
  • Brian P. Callahan
Published online: November 15, 2022
102705

November 14, 2022

Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors

  • Amy Moore,
  • Michael P. Busch,
  • Karolina Dziewulska,
  • ...
  • James C. Zimring,
  • Angelo D’Alessandro,
  • Grier P. Page
Published online: November 14, 2022
102706

Half-calcified calmodulin promotes basal activity and inactivation of the L-type calcium channel CaV1.2

  • Peter Bartels,
  • Ian Salveson,
  • Andrea M. Coleman,
  • ...
  • Mary C. Horne,
  • Johannes W. Hell,
  • James B. Ames
Published online: November 14, 2022
102701

Diptoindonesin G is a middle domain HSP90 modulator for cancer treatment

  • Kristine Donahue,
  • Haibo Xie,
  • Miyang Li,
  • ...
  • Lingjun Li,
  • Weiping Tang,
  • Wei Xu
Published online: November 14, 2022
102700

November 12, 2022

Toll-like receptor 4 and lipopolysaccharide from commensal microbes regulate Tembusu virus infection

  • Zhen Wu,
  • Tao Hu,
  • Andres Merits,
  • ...
  • Yanling Yu,
  • Anchun Cheng,
  • Shun Chen
Published online: November 12, 2022
102699

On the illusion of auxotrophy: met15Δ yeast cells can grow on inorganic sulfur thanks to the previously uncharacterized homocysteine synthase Yll058w

  • S. Branden Van Oss,
  • Saurin Bipin Parikh,
  • Nelson Castilho Coelho,
  • ...
  • Andrew P. VanDemark,
  • Gina M. DeNicola,
  • Anne-Ruxandra Carvunis
Published online: November 12, 2022
102697

November 11, 2022

Programmed death ligand 1 intracellular interactions with STAT3 and focal adhesion protein Paxillin facilitate lymphatic endothelial cell remodeling

  • Johnathon B. Schafer,
  • Erin D. Lucas,
  • Monika Dzieciettkowska,
  • Tadg Forward,
  • Beth A. Jirón Tamburini
Published online: November 11, 2022
102694

November 10, 2022

Loss of transcription factor TFEB dysregulates the G1/S transition and DNA replication in mammary epithelial cells

  • Logan Slade,
  • Dipsikha Biswas,
  • Petra C. Kienesberger,
  • Thomas Pulinilkunnil
Published online: November 10, 2022
102692

Role of the membrane anchor in the regulation of Lck activity

  • Nicla Porciello,
  • Deborah Cipria,
  • Giulia Masi,
  • ...
  • Nicolas Destainville,
  • Oreste Acuto,
  • Konstantina Nika
Published online: November 10, 2022
102663

November 9, 2022

A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers

A penetratin-derived peptide against α-synuclein oligomers

  • Mitra Pirhaghi,
  • Signe Andrea Frank,
  • Parvez Alam,
  • ...
  • Deepak Sharma,
  • Ali Akbar Saboury,
  • Daniel Erik Otzen
Published online: November 09, 2022
102688

November 8, 2022

Transmembrane anterior posterior transformation 1 (TAPT1) regulates BMP signaling and modulates the protein stability of SMAD1/5

  • Bo Wang,
  • Qian Zhao,
  • Xiaoxia Gong,
  • ...
  • Hongying Wang,
  • Jianfeng Zhou,
  • Xiaozhi Rong
Published online: November 08, 2022
102684

November 7, 2022

Cartwheel disassembly regulated by CDK1-Cyclin B kinase allows human centriole disengagement and licensing

  • Fan Huang,
  • Xiaowei Xu,
  • Guangwei Xin,
  • Boyan Zhang,
  • Qing Jiang,
  • Chuanmao Zhang
Published online: November 07, 2022
102658

November 3, 2022

Brain-Derived Neurotrophic Factor stimulates the retrograde pathway for axonal autophagy

  • David Kader Sidibe,
  • Vineet Vinay Kulkarni,
  • Audrey Dong,
  • ...
  • Maria Chalokh Vogel,
  • Max Henry Stempel,
  • Sandra Maday
Published online: November 03, 2022
102673

November 2, 2022

Mutations in the α4-α5 allosteric lobe of RAS do not significantly impair RAS signaling or self-association

  • Michael Whaby,
  • Lauren Wallon,
  • Megan Mazzei,
  • ...
  • Kai Wen Teng,
  • Shohei Koide,
  • John P. O’Bryan
Published online: November 02, 2022
102661

Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles

  • Lindsey A. Lee,
  • Samantha K. Barrick,
  • Artur Meller,
  • ...
  • Michael A. Geeves,
  • Michael J. Greenberg,
  • Leslie A. Leinwand
Published online: November 02, 2022
102657

Flow cytometric reporter assays provide robust functional analysis of signaling complexes

  • Timothy W. Muusse,
  • Morris Y.L. Lee,
  • Hyoyoung Kim,
  • ...
  • Bostjan Kobe,
  • Parimala R. Vajjhala,
  • Katryn J. Stacey
Published online: November 02, 2022
102666

October 19, 2022

Structural studies of human fission protein FIS1 reveal a dynamic region important for GTPase DRP1 recruitment and mitochondrial fission

  • John M. Egner,
  • Kelsey A. Nolden,
  • Megan C. Harwig,
  • ...
  • Gerard C.L. Wong,
  • Michael E. Widlansky,
  • R. Blake Hill
Published online: October 19, 2022
102620

March 3, 2022

Advertisement