May 08, 2020

2020 Editorial Board
Published in issue: May 08, 2020
i-iii

Author Index
Published in issue: May 08, 2020
vii-viii

Editors' Picks Highlights

Targeting the polyamine pathway—“a means” to overcome chemoresistance in triple-negative breast cancer
• Colleen Sweeney
Published in issue: May 08, 2020
p6278-6279

Editors' Picks

A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis
• Wanting Jiao,
• Yifei Fan,
• Nicola J. Blackmore,
• Emily J. Parker
Published in issue: May 08, 2020
p6252-6262

Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy
• Renee C. Geck,
• Jackson R. Foley,
• Tracy Murray Stewart,
• John M. Asara,
• Robert A. Casero Jr.,
• Alex Toker
Published in issue: May 08, 2020
p6263-6277

JBC Reviews

Brain manganese and the balance between essential roles and neurotoxicity
• Rekha C. Balachandran,
• Somshuvra Mukhopadhyay,
• Danielle McBride,
• ...
• Michael Aschner,
• Erin N. Haynes,
• Aaron B. Bowman
Published in issue: May 08, 2020
p6312-6329

Genetic lineage tracing with multiple DNA recombinases: A user's guide for conducting more precise cell fate mapping studies
• Kuo Liu,
• Hengwei Jin,
• Bin Zhou
Published in issue: May 08, 2020
p6413-6424

Templated folding of intrinsically disordered proteins
• Angelo Toto,
• Francesca Malagrinò,
• Lorenzo Visconti,
• ...
• Maurizio Brunori,
• Per Jemth,
• Stefano Gianni
Published in issue: May 08, 2020
p6586-6593

Letters to the Editor

Non-enzymatic action of expansins
• Daniel J. Cosgrove
Published in issue: May 08, 2020
p6782
Reply to Cosgrove: Non-enzymatic action of expansins
• Vivek S. Bharadwaj,
• Brandon C. Knott,
• Jerry Ståhlberg,
• Gregg T. Beckham,
• Michael F. Crowley
Published in issue: May 08, 2020
p6783

Cell Biology

Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells
• Aastha Kapoor,
• Carolyn G. Chen,
• Renato V. Iozzo
Published in issue: May 08, 2020
p6344-6356

An arrestin-1 surface opposite of its interface with photoactivated rhodopsin engages with enolase-1
• Connie Jaqueline Miranda,
• Nicole Fernandez,
• Nader Kamel,
• ...
• Jacob T. Andring,
• Robert McKenna,
• W. Clay Smith
Published in issue: May 08, 2020
p6498-6508

The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress
• Hakjoo Lee,
• Sylvia B. Smith,
• Shey-Shing Sheu,
• Yisang Yoon
Published in issue: May 08, 2020
p6543-6560

A kinesin adapter directly mediates dendritic mRNA localization during neural development in mice
• Hao Wu,
• Jing Zhou,
• Tianhui Zhu,
• Ivan Cohen,
• Jason Dictenberg
Published in issue: May 08, 2020
p6605-6628

The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca²⁺–NFATc1 axis
• Anna Ballard,
• Rong Zeng,
• Allahdad Zarei,
• ...
• Gerald W. Dorn II,
• Roberta Faccio,
• Deborah J. Veis
Published in issue: May 08, 2020
p6629-6640

A flexible network of vimentin intermediate filaments promotes migration of amoeboid cancer cells through confined environments
• Sandrine B. Lavenus,
• Sara M. Tudor,
• Maria F. Ullo,
• Karl W. Vosatka,
• Jeremy S. Logue
Published in issue: May 08, 2020
p6700-6709

SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation
• Rui Wu,
• Jiali Fang,
• Mingcheng Liu,
• ...
• Baotong Zhang,
• Liya Fu,
• Jin-Tang Dong
Published in issue: May 08, 2020
p6741-6753

Developmental Biology

The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis
• Qian Gao,
• Ranjha Khan,
• Changping Yu,
• ...
• Xiaohua Jiang,
• Hui Ma,
• Qinghua Shi
Published in issue: May 08, 2020
p6289-6298

Enzymology

Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations
• Pramod Kumar Yadav,
• Victor Vitvitsky,
• Sebastián Carballal,
• Javier Seravalli,
• Ruma Banerjee
Published in issue: May 08, 2020
p6299-6311

Roles of active-site residues in catalysis, substrate binding, cooperativity, and the reaction mechanism of the quinoprotein glycine oxidase
• Kyle J. Mamounis,
• Erik T. Yukl,
• Victor L. Davidson
Published in issue: May 08, 2020
p6472-6481

Quantification of the affinities of CRISPR–Cas9 nucleases for cognate protospacer adjacent motif (PAM) sequences
• Vladimir Mekler,
• Konstantin Kuznedelov,
• Konstantin Severinov
Published in issue: May 08, 2020
p6509-6517

Crystallographic and kinetic analyses of the FdsBG subcomplex of the cytosolic formate dehydrogenase FdsABG from Cupriavidus necator
• Tynan Young,
• Dimitri Niks,
• Sheron Hakopian,
• ...
• Xuejun Yu,
• Russ Hille,
• Gregor M. Blaha
Published in issue: May 08, 2020
p6570-6585

Spectral and photochemical diversity of tandem cysteine cyanobacterial phytochromes
• Ji-Young Song,
• Ha Yong Lee,
• Hee Wook Yang,
• Ji-Joon Song,
• J. Clark Lagarias,
• Youn-Il Park
Published in issue: May 08, 2020
p6754-6766

Gene Regulation

Inflammatory and mitogenic signals drive interleukin 23 subunit alpha (IL23A) secretion independent of IL12B in intestinal epithelial cells
• Kee Siang Lim,
• Zachary Wei Ern Yong,
• Huajing Wang,
• ...
• Masanobu Oshima,
• Yoshiaki Ito,
• Dominic Chih-Cheng Voon
Published in issue: May 08, 2020
p6387-6400

The histone H4 basic patch regulates SAGA-mediated H2B deubiquitination and histone acetylation
• Hashem A. Meriesh,
• Andrew M. Lerner,
• Mahesh B. Chandrasekharan,
• Brian D. Strahl
Published in issue: May 08, 2020
p6561-6569

Glycobiology and Extracellular Matrices

Inhibition of glycosphingolipid biosynthesis reverts multidrug resistance by differentially modulating ABC transporters in chronic myeloid leukemias
• Eduardo J. Salustiano,
• Kelli M. da Costa,
• Leonardo Freire-de-Lima,
• Lucia Mendonça-Previato,
• José O. Previato
Published in issue: May 08, 2020
p6457-6471

ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface
• Jinling Yang,
• Michelle E. LeBlanc,
• Issahy Cano,
• ...
• Magali Saint-Geniez,
• Yin-Shan Ng,
• Patricia A. D'Amore
Published in issue: May 08, 2020
p6641-6651

Structural basis of substrate recognition and catalysis by fucosyltransferase 8
• Michael A. Järvå,
• Marija Dramicanin,
• James P. Lingford,
• ...
• Kate E. Jarman,
• Rhys Grinter,
• Ethan D. Goddard-Borger
Published in issue: May 08, 2020
p6677-6688

Metabolism

Perturbation of phosphoglycerate kinase 1 (PGK1) only marginally affects glycolysis in cancer cells
• Chengmeng Jin,
• Xiaobing Zhu,
• Hao Wu,
• Yuqi Wang,
• Xun Hu
Published in issue: May 08, 2020
p6425-6446

Methods and Resources

Chemical roadblocking of DNA transcription for nascent RNA display
• Eric J. Strobel,
• John T. Lis,
• Julius B. Lucks
Published in issue: May 08, 2020
p6401-6412

Microbiology

The major subunit of widespread competence pili exhibits a novel and conserved type IV pilin fold
• Devon Sheppard,
• Jamie-Lee Berry,
• Rémi Denise,
• Eduardo P.C. Rocha,
• Steve Matthews,
• Vladimir Pelicic
Published in issue: May 08, 2020
p6594-6604

Molecular Bases of Disease

A neuroglobin-based high-affinity ligand trap reverses carbon monoxide–induced mitochondrial poisoning
• Jason J. Rose,
• Kaitlin A. Bocian,
• Qinzi Xu,
• ...
• Jesús Tejero,
• Sruti Shiva,
• Mark T. Gladwin
Published in issue: May 08, 2020
p6357-6371

Pro-515 of the dynamin-like GTPase MxB contributes to HIV-1 inhibition by regulating MxB oligomerization and binding to HIV-1 capsid
• Fengwen Xu,
• Fei Zhao,
• Xiaoxiao Zhao,
• ...
• Shan Cen,
• Chen Liang,
• Fei Guo
Published in issue: May 08, 2020
p6447-6456

Non-photopic and photopic visual cycles differentially regulate immediate, early, and late phases of cone photoreceptor-mediated vision
• Rebecca Ward,
• Joanna J. Kaylor,
• Diego F. Cobice,
• ...
• James B. Hurley,
• Gabriel H. Travis,
• Breandán N. Kennedy
Published in issue: May 08, 2020
p6482-6497

Effects of deficiency in the RLBP1-encoded visual cycle protein CRALBP on visual dysfunction in humans and mice
• Jose Ronaldo Lima de Carvalho Jr.,
• Hye Jin Kim,
• Keiko Ueda,
• ...
• Tingting Yang,
• Stephen H. Tsang,
• Janet R. Sparrow
Published in issue: May 08, 2020
p6767-6780

Molecular Biophysics

Tracking isotopically labeled oxidants using boronate-based redox probes
• Natalia Rios,
• Rafael Radi,
• Balaraman Kalyanaraman,
• Jacek Zielonka
Published in issue: May 08, 2020
p6665-6676

Neurobiology

Reactive dicarbonyl compounds cause Calcitonin Gene-Related Peptide release and synergize with inflammatory conditions in mouse skin and peritoneum
• Anna K. Becker,
• Andrea Auditore,
• Monika Pischetsrieder,
• ...
• Thomas Fleming,
• Peter W. Reeh,
• Susanne K. Sauer
Published in issue: May 08, 2020
p6330-6343

α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species
• Sophie A. Morgan,
• Isabelle Lavenir,
• Juan Fan,
• ...
• Dennis W. Dickson,
• Bernardino Ghetti,
• Michel Goedert
Published in issue: May 08, 2020
p6652-6664

Roles of the DOCK-D family proteins in a mouse model of neuroinflammation
• Kazuhiko Namekata,
• Xiaoli Guo,
• Atsuko Kimura,
• ...
• Yuta Kitamura,
• Chikako Harada,
• Takayuki Harada
Published in issue: May 08, 2020
p6710-6720

Protein Structure and Folding

The streptococcal multidomain fibrillar adhesin CshA has an elongated polymeric architecture
• Catherine R. Back,
• Victoria A. Higman,
• Kristian Le Vay,
• ...
• Matthew P. Crump,
• Angela H. Nobbs,
• Paul R. Race
Published in issue: May 08, 2020
p6689-6699

RNA

A kainate receptor–selective RNA aptamer
• William Jaremko,
• Zhen Huang,
• Nicholas Karl,
• Vincen D. Pierce,
• Janet Lynch,
• Li Niu
Published in issue: May 08, 2020
p6280-6288

RNA helicase–regulated processing of the Synechocystis rimO–crhR operon results in differential cistron expression and accumulation of two sRNAs
• Albert Remus R. Rosana,
• Denise S. Whitford,
• Anzhela Migur,
• ...
• Sonya L. Kujat-Choy,
• Wolfgang R. Hess,
• George W. Owttrim
Published in issue: May 08, 2020
p6372-6386

Signal Transduction

Phosphoproteomic characterization of the signaling network resulting from activation of the chemokine receptor CCR2
• Cheng Huang,
• Simon R. Foster,
• Anup D. Shah,
• ...
• Meritxell Canals,
• Ralf B. Schittenhelm,
• Martin J. Stone
Published in issue: May 08, 2020
p6518-6531

Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors
• Sean Jmaeff,
• Yulia Sidorova,
• Hinyu Nedev,
• Mart Saarma,
• H. Uri Saragovi
Published in issue: May 08, 2020
p6532-6542

Polarization of protease-activated receptor 2 (PAR-2) signaling is altered during airway epithelial remodeling and deciliation
• Ryan M. Carey,
• Jenna R. Freund,
• Benjamin M. Hariri,
• Nithin D. Adappa,
• James N. Palmer,
• Robert J. Lee
Published in issue: May 08, 2020
p6721-6740

Additions and Corrections

Correction: Histone demethylase KDM6B promotes epithelial-mesenchymal transition.
• Sivakumar Ramadoss,
• Xiaohong Chen,
• Cun-Yu Wang
Published in issue: May 08, 2020
p6781
Correction: Rational design, synthesis, and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase.
• Lukas Gorecki,
• Oksana Gerlits,
• Xiaotian Kong,
• ...
• Carlo Ballatore,
• Andrey Kovalevsky,
• Zoran Radić
Published in issue: May 08, 2020
p6784