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December 11, 2020

Volume 295Issue 50p16906-17382
Open Access
On The Cover: SARS-CoV-2 main protease is shaped like a valentine's heart and ironically functions as the “heart” of the virus by cleaving large polyprotein chains into viable nonstructural viral proteins during the virus replication. The enzyme is a target for the design of specific protease inhibitors that bind to the unusual zwitterionic catalytic site revealed by neutron crystallography at near-physiological temperature. For details, see the article by Kneller et al., pages 17365–17373....
On The Cover: SARS-CoV-2 main protease is shaped like a valentine's heart and ironically functions as the “heart” of the virus by cleaving large polyprotein chains into viable nonstructural viral proteins during the virus replication. The enzyme is a target for the design of specific protease inhibitors that bind to the unusual zwitterionic catalytic site revealed by neutron crystallography at near-physiological temperature. For details, see the article by Kneller et al., pages 17365–17373.

Editors' Picks Highlights

Editors' Picks

JBC Reviews

Accelerated Communications

Cell Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

Neurobiology

Protein Structure and Folding

Protein Synthesis and Degradation

RNA

Signal Transduction

Additions and Corrections

Withdrawals/Retractions

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