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April 27, 2007

Volume 282Issue 17p12353-13140, e12-e14, e99911
Open Access
On The Cover: The interaction between the polysaccharide hyaluronan (contoured in red) and the Link module domain of human TSG-6 (green), an anti-inflammatory protein with a critical role in ovulation, is maximal at pH 6. In the article by Blundell et al., pages 12976–12988, the pH dependence was shown to result from a hydrogen bond network transmitting the change in ionization state of a histidine (blue), via an aspartate (dark green), to a key tyrosine residue (yellow) in the hyaluronan-binding site. The illustration was provided by David Briggs....
On The Cover: The interaction between the polysaccharide hyaluronan (contoured in red) and the Link module domain of human TSG-6 (green), an anti-inflammatory protein with a critical role in ovulation, is maximal at pH 6. In the article by Blundell et al., pages 12976–12988, the pH dependence was shown to result from a hydrogen bond network transmitting the change in ionization state of a histidine (blue), via an aspartate (dark green), to a key tyrosine residue (yellow) in the hyaluronan-binding site. The illustration was provided by David Briggs.

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Classics

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DNA: Replication, Repair, and Recombination

Genes: Structure and Regulation

Protein Synthesis, Post-Translation Modification, and Degradation

Protein Structure and Folding

Enzyme Catalysis and Regulation

Metabolism and Bioenergetics

Glycobiology and Extracellular Matrices

Membrane Transport, Structure, Function, and Biogenesis

Molecular Basis of Cell and Developmental Biology

Mechanisms of Signal Transduction

Additions and Corrections

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