April 27, 2007
Volume 282Issue 17p12353-13140, e12-e14, e99911
Open Access
On The Cover: The interaction between the polysaccharide hyaluronan (contoured in red) and the Link module domain of human TSG-6 (green), an anti-inflammatory protein with a critical role in ovulation, is maximal at pH
6. In the article by Blundell et al., pages 12976–12988, the pH dependence was shown to result from a hydrogen bond network transmitting
the change in ionization state of a histidine (blue), via an aspartate (dark green), to a key tyrosine residue (yellow) in the hyaluronan-binding site. The illustration was provided by David Briggs....Show more
On The Cover: The interaction between the polysaccharide hyaluronan (contoured in red) and the Link module domain of human TSG-6 (green), an anti-inflammatory protein with a critical role in ovulation, is maximal at pH
6. In the article by Blundell et al., pages 12976–12988, the pH dependence was shown to result from a hydrogen bond network transmitting
the change in ionization state of a histidine (blue), via an aspartate (dark green), to a key tyrosine residue (yellow) in the hyaluronan-binding site. The illustration was provided by David Briggs.
