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September 01, 2006

Volume 281Issue 35p25001-25868
Open Access
On The Cover: The malarial parasite Plasmodium falciparum is transmitted by the bite of the anopheline mosquito. Falcipain-2 is a cysteine protease from P. falciparum that plays a critical role in the parasite life cycle by degrading proteins of the host erythrocyte, notably hemoglobin. The structural and functional characterization of falcipain-2 opens new avenues for the rational design of novel antimalarial drugs. For details see the article by Hogg et al., pages 25425–25437....
On The Cover: The malarial parasite Plasmodium falciparum is transmitted by the bite of the anopheline mosquito. Falcipain-2 is a cysteine protease from P. falciparum that plays a critical role in the parasite life cycle by degrading proteins of the host erythrocyte, notably hemoglobin. The structural and functional characterization of falcipain-2 opens new avenues for the rational design of novel antimalarial drugs. For details see the article by Hogg et al., pages 25425–25437.

Minireview

Accelerated Publication

DNA: Replication, Repair, and Recombination

Genes: Structure and Regulation

RNA: Structure, Metabolism, and Catalysis

Protein Synthesis, Post-Translation Modification, and Degradation

Genomics, Proteomics, and Bioinformatics

Protein Structure and Folding

Enzyme Catalysis and Regulation

Metabolism and Bioenergetics

Glycobiology and Extracellular Matrices

Lipids and Lipoproteins

Membrane Transport, Structure, Function, and Biogenesis

Mechanisms of Signal Transduction

Molecular Basis of Cell and Developmental Biology

Additions and Corrections

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