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February 13, 2015

Volume 290Issue 7p3875-4536
Open Access
On The Cover: The anaerobic sulfatase-maturating enzyme (anSMEcpe) uses radical chemistry to install a post-translational modification, the addition of a catalytically essential formylglycine moiety, on a sulfatase protein substrate. The structure of this enzyme enhances our understanding of a largely uncharacterized, diverse AdoMet radical subfamily that modifies ribosomally translated peptides. For details see the article by Grell et al., pages 3964–3971....
On The Cover: The anaerobic sulfatase-maturating enzyme (anSMEcpe) uses radical chemistry to install a post-translational modification, the addition of a catalytically essential formylglycine moiety, on a sulfatase protein substrate. The structure of this enzyme enhances our understanding of a largely uncharacterized, diverse AdoMet radical subfamily that modifies ribosomally translated peptides. For details see the article by Grell et al., pages 3964–3971.

Papers of the Week

Minireviews

Bioenergetics

Cell Biology

Developmental Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Immunology

Lipids

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Protein Structure and Folding

RNA

Signal Transduction

Additions and Corrections

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