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January 06, 2006

Volume 281Issue 1p1-676, e1-e3
Open Access
The cover shows three-dimensional acini of the mammary epithelial cell line MCF-10A. These images represent one acinus at different cross-sections with respect to the z-axis. At day 14, a single polarized cell layer surrounds a hollow lumen, a process of morphogenesis that requires both tightly regulated proliferation and apoptosis of the central matrix-detached cells. The TOPRO-3 stained acinus (blue) shows membranous localization of β-catenin (red). For details see the article by Brummer et al., pages 626–637....
The cover shows three-dimensional acini of the mammary epithelial cell line MCF-10A. These images represent one acinus at different cross-sections with respect to the z-axis. At day 14, a single polarized cell layer surrounds a hollow lumen, a process of morphogenesis that requires both tightly regulated proliferation and apoptosis of the central matrix-detached cells. The TOPRO-3 stained acinus (blue) shows membranous localization of β-catenin (red). For details see the article by Brummer et al., pages 626–637.

Classics

Minireviews

Accelerated Publications

DNA: Replication, Repair, and Recombination

Genes: Structure and Regulation

RNA: Structure, Metabolism, and Catalysis

Protein Synthesis, Post-Translation Modification, and Degradation

Protein Structure and Folding

Enzyme Catalysis and Regulation

Metabolism and Bioenergetics

Glycobiology and Extracellular Matrices

Lipids and Lipoproteins

Membrane Transport, Structure, Function, and Biogenesis

Molecular Basis of Cell and Developmental Biology

Mechanisms of Signal Transduction

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