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July 22, 2011

Volume 286Issue 29p25417-26266, e6-e8, e99957
Open Access
On The Cover: The circadian clock is the internal timekeeping molecular system that generates a daily rhythm in an organism's physiology and behavior. Based on genetic and cell biological experiments, a canonical model for the circadian clock in mammals consisting of TTFL has been developed. The paper by Rui Ye and colleagues describes the purification of the mammalian clock proteins and the first biochemical test of the model. Their findings support some aspects of the canonical model but also suggest that some key features of the model need to be revised. The cover picture is a whimsical illustration of the significance of biochemical analysis to the understanding of this complex behavioral system. For details see the article by Ye et al., pages 25891–25902....
On The Cover: The circadian clock is the internal timekeeping molecular system that generates a daily rhythm in an organism's physiology and behavior. Based on genetic and cell biological experiments, a canonical model for the circadian clock in mammals consisting of TTFL has been developed. The paper by Rui Ye and colleagues describes the purification of the mammalian clock proteins and the first biochemical test of the model. Their findings support some aspects of the canonical model but also suggest that some key features of the model need to be revised. The cover picture is a whimsical illustration of the significance of biochemical analysis to the understanding of this complex behavioral system. For details see the article by Ye et al., pages 25891–25902.

Papers of the Week

Minireviews

Classics

Cell Biology

Computational Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Lipids

Metabolism

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Plant Biology

Protein Structure and Folding

Protein Synthesis and Degradation

RNA

Signal Transduction

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