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May 10, 2013

Volume 288Issue 19p13675-13849
Open Access
On The Cover: The image depicts a single-molecule DNA supercoil relaxation experiment with human topoisomerase IIα (red, model based on PDB codes 1ZXM, 4FM9, and 1ZVU). Individual DNA molecules (green) attached to magnetic beads (gray) are supercoiled (DNA in foreground) by rotating external magnets (not shown). Human topoisomerase IIα relaxes positively supercoiled DNA faster than negatively supercoiled DNA. For details, see the article by Seol et al., pages 13695–13703....
On The Cover: The image depicts a single-molecule DNA supercoil relaxation experiment with human topoisomerase IIα (red, model based on PDB codes 1ZXM, 4FM9, and 1ZVU). Individual DNA molecules (green) attached to magnetic beads (gray) are supercoiled (DNA in foreground) by rotating external magnets (not shown). Human topoisomerase IIα relaxes positively supercoiled DNA faster than negatively supercoiled DNA. For details, see the article by Seol et al., pages 13695–13703.

Papers of the Week

Minireviews

Reports

Cell Biology

Computational Biology

Developmental Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Lipids

Metabolism

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Protein Structure and Folding

Protein Synthesis and Degradation

RNA

Signal Transduction

Additions and Corrections

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