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February 07, 2014

Volume 289Issue 6p3105-3827
Open Access
On The Cover: The unfolded protein response (UPR) and HIF pathways were analyzed in a human neuroblastoma xenograft tumor. Transcripts for BNIP3 (red, HIF target) and CHOP (blue, UPR target) were detected by in situ hybridization. Blood vessels were identified by CD34 staining (brown). The maroon signal away from the blood vessels indicates an overlap between the two pathways, whereas UPR activation (blue) is observed throughout the tumor. For details see the article by Pereira et al., pages 3352–3364....
On The Cover: The unfolded protein response (UPR) and HIF pathways were analyzed in a human neuroblastoma xenograft tumor. Transcripts for BNIP3 (red, HIF target) and CHOP (blue, UPR target) were detected by in situ hybridization. Blood vessels were identified by CD34 staining (brown). The maroon signal away from the blood vessels indicates an overlap between the two pathways, whereas UPR activation (blue) is observed throughout the tumor. For details see the article by Pereira et al., pages 3352–3364.

Papers of the week

Letters

Cell Biology

Developmental Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Protein Structure and Folding

Protein Synthesis and Degradation

RNA

Signal Transduction

Additions and Corrections

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