February 07, 2014
Volume 289Issue 6p3105-3827
Open Access
On The Cover: The unfolded protein response (UPR) and HIF pathways were analyzed in a human neuroblastoma
xenograft tumor. Transcripts for BNIP3 (red, HIF target) and CHOP (blue, UPR target) were detected by in situ hybridization. Blood vessels were identified by CD34 staining (brown). The maroon signal away from the blood vessels indicates an overlap between the two pathways,
whereas UPR activation (blue) is observed throughout the tumor. For details see the article by Pereira et al., pages 3352–3364....Show more
On The Cover: The unfolded protein response (UPR) and HIF pathways were analyzed in a human neuroblastoma
xenograft tumor. Transcripts for BNIP3 (red, HIF target) and CHOP (blue, UPR target) were detected by in situ hybridization. Blood vessels were identified by CD34 staining (brown). The maroon signal away from the blood vessels indicates an overlap between the two pathways,
whereas UPR activation (blue) is observed throughout the tumor. For details see the article by Pereira et al., pages 3352–3364.
