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June 26, 2009

Volume 284Issue 26p17365-17896, e8-e9, e99927-e99928
Open Access
On The Cover: View from the periplasm of the interface region between the substrate-binding protein MalE (green) and the MalF-P2 loop (red) in the crystal structure (Protein Data Bank code 2R6G). The energetically favored spin label rotamers used to simulate interspin distance distributions are depicted as stick models for each position investigated. Two double electron-electron resonance (DEER) traces are shown connecting two pairs of spin-labeled sites, exemplificative of the long range distance constraints (2-8 nm) detectable by EPR during the substrate translocation process. For details see the article by Grote et al., pages 17521–17526....
On The Cover: View from the periplasm of the interface region between the substrate-binding protein MalE (green) and the MalF-P2 loop (red) in the crystal structure (Protein Data Bank code 2R6G). The energetically favored spin label rotamers used to simulate interspin distance distributions are depicted as stick models for each position investigated. Two double electron-electron resonance (DEER) traces are shown connecting two pairs of spin-labeled sites, exemplificative of the long range distance constraints (2-8 nm) detectable by EPR during the substrate translocation process. For details see the article by Grote et al., pages 17521–17526.

Papers of the Week

Classics

Minireview

DNA: Replication, Repair, Recombination, and Chromosome Dynamics

Transcription, Chromatin, and Epigenetics

RNA: Processing and Catalysis

Protein Synthesis, Post-Translational Modification, and Degradation

Genomics, Proteomics, and Bioinformatics

Protein Structure and Folding

Enzyme Catalysis and Regulation

Metabolism and Bioenergetics

Glycobiology and Extracellular Matrices

Lipids and Lipoproteins: Metabolism, Regulation, and Signaling

Membrane Transport, Structure, Function, and Biogenesis

Molecular Basis of Cell and Developmental Biology

Mechanisms of Signal Transduction

Biomolecular Networks

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