July 20, 2018

Editorial Board
Published in issue: July 20, 2018
i-iii

Author Index
Published in issue: July 20, 2018
vii-viii

Cell Biology

An allosteric propofol-binding site in kinesin disrupts kinesin-mediated processive movement on microtubules
• Kellie A. Woll,
• Stephanie Guzik-Lendrum,
• Brandon M. Bensel,
• ...
• Benjamin A. Garcia,
• Susan P. Gilbert,
• Roderic G. Eckenhoff
Published in issue: July 20, 2018
p11283-11295

Analysis of heat-induced protein aggregation in human mitochondria
• Anne Wilkening,
• Cornelia Rüb,
• Marc Sylvester,
• Wolfgang Voos
Published in issue: July 20, 2018
p11537-11552

Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol
• Ana G. Pedrosa,
• Tânia Francisco,
• Diana Bicho,
• ...
• Gabriele Dodt,
• Tony A. Rodrigues,
• Jorge E. Azevedo
Published in issue: July 20, 2018
p11553-11563

Computational Biology

Conformational changes allow processing of bulky substrates by a haloalkane dehalogenase with a small and buried active site
• Piia Kokkonen,
• David Bednar,
• Veronika Dockalova,
• Zbynek Prokop,
• Jiri Damborsky
Published in issue: July 20, 2018
p11505-11512

Enzymology

Intermolecular autocatalytic activation of serine protease zymogen factor C through an active transition state responding to lipopolysaccharide
• Toshio Shibata,
• Yuki Kobayashi,
• Yuto Ikeda,
• Shun-ichiro Kawabata
Published in issue: July 20, 2018
p11589-11599

Gene Regulation

Interleukin-like EMT inducer (ILEI) promotes melanoma invasiveness and is transcriptionally up-regulated by upstream stimulatory factor-1 (USF-1)
• Ken Noguchi,
• Toros A. Dincman,
• Annamarie C. Dalton,
• ...
• Buckley J. McCall,
• Bidyut K. Mohanty,
• Philip H. Howe
Published in issue: July 20, 2018
p11401-11414

Genomics and Proteomics

Chemoproteomics of matrix metalloproteases in a model of cartilage degeneration suggests functional biomarkers associated with posttraumatic osteoarthritis
• Kodihalli C. Ravindra,
• Caroline C. Ahrens,
• Yang Wang,
• ...
• Linda G. Griffith,
• Alan J. Grodzinsky,
• Steven R. Tannenbaum
Published in issue: July 20, 2018
p11459-11469

Glycobiology and Extracellular Matrices

Identification of novel binding sites for heparin in receptor protein-tyrosine phosphatase (RPTPσ): Implications for proteoglycan signaling
• Yasuhiro Katagiri,
• Ashlea A. Morgan,
• Panpan Yu,
• Nathanael J. Bangayan,
• Radoslaw Junka,
• Herbert M. Geller
Published in issue: July 20, 2018
p11639-11647

Immunology

Tribbles homolog 1 deficiency modulates function and polarization of murine bone marrow–derived macrophages
• Lilli Arndt,
• Janine Dokas,
• Martin Gericke,
• ...
• Franziska Jeromin,
• Joachim Thiery,
• Ralph Burkhardt
Published in issue: July 20, 2018
p11527-11536

Lipids

Choline transport links macrophage phospholipid metabolism and inflammation
• Shayne A. Snider,
• Kaitlyn D. Margison,
• Peyman Ghorbani,
• ...
• Hongbin Xu,
• Steffany A.L. Bennett,
• Morgan D. Fullerton
Published in issue: July 20, 2018
p11600-11611

Membrane Biology

The architecture of the OmpC–MlaA complex sheds light on the maintenance of outer membrane lipid asymmetry in Escherichia coli
• Jiang Yeow,
• Kang Wei Tan,
• Daniel A. Holdbrook,
• ...
• Jan K. Marzinek,
• Peter J. Bond,
• Shu-Sin Chng
Published in issue: July 20, 2018
p11325-11340

Metabolism

Salmonella enterica serovar Typhimurium has three transketolase enzymes contributing to the pentose phosphate pathway
• Jeff A. Shaw,
• Calvin A. Henard,
• Lin Liu,
• Lynne M. Dieckman,
• Andrés Vázquez-Torres,
• Travis J. Bourret
Published in issue: July 20, 2018
p11271-11282

Microbiology

Specific binding between Bacillus thuringiensis Cry9Aa and Vip3Aa toxins synergizes their toxicity against Asiatic rice borer (Chilo suppressalis)
• Zeyu Wang,
• Longfa Fang,
• Zishan Zhou,
• ...
• Mario Soberón,
• Jie Zhang,
• Alejandra Bravo
Published in issue: July 20, 2018
p11447-11458

Structural and functional characterization of PL28 family ulvan lyase NLR48 from Nonlabens ulvanivorans
• ThirumalaiSelvi Ulaganathan,
• Ehud Banin,
• William Helbert,
• Miroslaw Cygler
Published in issue: July 20, 2018
p11564-11573

Molecular Bases of Disease

Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes
• Lauren K. Fong,
• Max M. Yang,
• Rodrigo dos Santos Chaves,
• ...
• Elizabeth A. Roberts,
• Jessica E. Young,
• Lawrence S.B. Goldstein
Published in issue: July 20, 2018
p11341-11357

Heme and hemoglobin suppress amyloid β–mediated inflammatory activation of mouse astrocytes
• Sitara B. Sankar,
• Rebecca K. Donegan,
• Kajol J. Shah,
• Amit R. Reddi,
• Levi B. Wood
Published in issue: July 20, 2018
p11358-11373

A potential strategy for reducing cysts in autosomal dominant polycystic kidney disease with a CFTR corrector
• Murali K. Yanda,
• Qiangni Liu,
• Liudmila Cebotaru
Published in issue: July 20, 2018
p11513-11526

A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle
• Boglarka Racz,
• Andras Varadi,
• Jian Kong,
• ...
• Graham Johnson,
• Christopher L. Cioffi,
• Konstantin Petrukhin
Published in issue: July 20, 2018
p11574-11588

Molecular Biophysics

A hydrophobic low-complexity region regulates aggregation of the yeast pyruvate kinase Cdc19 into amyloid-like aggregates in vitro
• Erica Grignaschi,
• Gea Cereghetti,
• Fulvio Grigolato,
• ...
• Shady Saad,
• Matthias Peter,
• Paolo Arosio
Published in issue: July 20, 2018
p11424-11432

The kinase activity of the channel-kinase protein TRPM7 regulates stability and localization of the TRPM7 channel in polarized epithelial cells
• Na Cai,
• Liping Lou,
• Namariq Al-Saadi,
• Sandra Tetteh,
• Loren W. Runnels
Published in issue: July 20, 2018
p11491-11504

Neurobiology

A role for proteolytic regulation of δ-catenin in remodeling a subpopulation of dendritic spines in the rodent brain
• Li Yuan,
• Dipika Singh,
• James L. Buescher,
• Jyothi Arikkath
Published in issue: July 20, 2018
p11625-11638

Protein Structure and Folding

Ovalbumin self-assembles into amyloid nanosheets that elicit immune responses and facilitate sustained drug release
• Saba Tufail,
• Mohd. Asif Sherwani,
• Shoaib Shoaib,
• Sarfuddin Azmi,
• Mohammad Owais,
• Najmul Islam
Published in issue: July 20, 2018
p11310-11324

Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer
• Murilo M. Pedrote,
• Guilherme A.P. de Oliveira,
• Adriani L. Felix,
• ...
• Enrico Gratton,
• Elio A. Cino,
• Jerson L. Silva
Published in issue: July 20, 2018
p11374-11387

Noncovalent interactions dominate dynamic heme distortion in cytochrome P450 4B1
• Gareth K. Jennings,
• Mei-Hui Hsu,
• Lisa S. Shock,
• Eric F. Johnson,
• John C Hackett
Published in issue: July 20, 2018
p11433-11446

Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase from Salmonella enterica
• Ana Laura Stern,
• Sander Egbert Van der Verren,
• Sandesh Kanchugal P,
• Joakim Näsvall,
• Hugo Gutiérrez-de-Terán,
• Maria Selmer
Published in issue: July 20, 2018
p11481-11490

Protein Synthesis and Degradation

Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1
• Suping Chen,
• Jing Yang,
• Yang Zhang,
• ...
• Ying Xu,
• Liang Zhou,
• Guoqiang Xu
Published in issue: July 20, 2018
p11296-11309

Signal Transduction

Multiple sequences orchestrate subcellular trafficking of neuronal PAS domain–containing protein 4 (NPAS4)
• Beata Greb-Markiewicz,
• Mirosław Zarębski,
• Andrzej Ożyhar
Published in issue: July 20, 2018
p11255-11270

High glucose reduces megalin-mediated albumin endocytosis in renal proximal tubule cells through protein kinase B O-GlcNAcylation
• Diogo de Barros Peruchetti,
• Rodrigo Pacheco Silva-Aguiar,
• Gabriela Marques Siqueira,
• Wagner Barbosa Dias,
• Celso Caruso-Neves
Published in issue: July 20, 2018
p11388-11400

Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages
• Amy T. Hsu,
• Tanya J. Lupancu,
• Ming-Chin Lee,
• ...
• Andrew D. Cook,
• John A. Hamilton,
• Adrian Achuthan
Published in issue: July 20, 2018
p11415-11423

Endocytosis is required for CXC chemokine receptor type 4 (CXCR4)-mediated Akt activation and antiapoptotic signaling
• Elizabeth J. English,
• Sarah A. Mahn,
• Adriano Marchese
Published in issue: July 20, 2018
p11470-11480

β₁Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells
• Pei-Yin Ho,
• Hui Li,
• Tengis S. Pavlov,
• ...
• Dietbert Neumann,
• Alexander Staruschenko,
• Kenneth R. Hallows
Published in issue: July 20, 2018
p11612-11624

Additions and Corrections

ADAMTS-12 metalloprotease is necessary for normal inflammatory response.
• Angela Moncada-Pazos,
• Alvaro J. Obaya,
• María Llamazares,
• ...
• Agnès Noël,
• Santiago Cal,
• Carlos López-Otín
Published in issue: July 20, 2018
p11648
Deletion of PsbM in tobacco alters the Q_B site properties and the electron flow within photosystem II.
• Pavan Umate,
• Serena Schwenkert,
• Izhar Karbat,
• ...
• Reinhold G. Herrmann,
• Itzhak Ohad,
• Jörg Meurer
Published in issue: July 20, 2018
p11649

First evidence for a covalent linkage between enterobacterial common antigen and lipopolysaccharide in Shigella sonnei phase II ECA_LPS.
• Tomasz K. Gozdziewicz,
• Czeslaw Lugowski,
• Jolanta Lukasiewicz
Published in issue: July 20, 2018
p11652-11653

Withdrawals/Retractions

Withdrawal: hSos1 contains a new amino-terminal regulatory motif with specific binding affinity for its pleckstrin homology domain.
• Rocío Jorge,
• Natasha Zarich,
• José Luis Oliva,
• ...
• Natalia Martínez,
• Xavier de la Cruz,
• José M. Rojas
Published in issue: July 20, 2018
p11650
Withdrawal: The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.
• José Luis Oliva,
• Natasha Zarich,
• Natalia Martínez,
• ...
• Lisardo Boscá,
• J. Silvio Gutkind,
• José M. Rojas
Published in issue: July 20, 2018
p11651