July 2017
Volume 292Issue 23p9441-9857
Open Access
On The Cover: Inhaled general anesthetics are administered by vaporization, upon which they reach
their site of action in the central nervous system. Study finds that they act first
by partitioning into the membrane, followed by traversing a membrane-embedded tunnel,
and finally binding to specific regions of ligand-gated ion channels, perturbing channel
structure to modulate ion translocation. For details see the article by Arcario et al., pages 9480–9492....Show more
On The Cover: Inhaled general anesthetics are administered by vaporization, upon which they reach
their site of action in the central nervous system. Study finds that they act first
by partitioning into the membrane, followed by traversing a membrane-embedded tunnel,
and finally binding to specific regions of ligand-gated ion channels, perturbing channel
structure to modulate ion translocation. For details see the article by Arcario et al., pages 9480–9492.
