October 27, 2017
Volume 292Issue 43p17577-17980
Open Access
On The Cover: Specific matrix metalloproteinase-9 (MMP-9) inhibitors could be powerful therapeutic
tools for several human diseases, but achieving specificity has been highly challenging.
A new approach of inhibiting the activation of the latent zymogen overcomes this obstacle.
Shown are space-filling and ribbon crystal structures of proMMP-9 with a novel inhibitor
unbound (left) and bound (right) and the resultant effects on a cellular invasion assay. For details, see the article
by Scannevin et al., pages 17963–17974....Show more
On The Cover: Specific matrix metalloproteinase-9 (MMP-9) inhibitors could be powerful therapeutic
tools for several human diseases, but achieving specificity has been highly challenging.
A new approach of inhibiting the activation of the latent zymogen overcomes this obstacle.
Shown are space-filling and ribbon crystal structures of proMMP-9 with a novel inhibitor
unbound (left) and bound (right) and the resultant effects on a cellular invasion assay. For details, see the article
by Scannevin et al., pages 17963–17974.
