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October 27, 2017

Volume 292Issue 43p17577-17980
Open Access
On The Cover: Specific matrix metalloproteinase-9 (MMP-9) inhibitors could be powerful therapeutic tools for several human diseases, but achieving specificity has been highly challenging. A new approach of inhibiting the activation of the latent zymogen overcomes this obstacle. Shown are space-filling and ribbon crystal structures of proMMP-9 with a novel inhibitor unbound (left) and bound (right) and the resultant effects on a cellular invasion assay. For details, see the article by Scannevin et al., pages 17963–17974....
On The Cover: Specific matrix metalloproteinase-9 (MMP-9) inhibitors could be powerful therapeutic tools for several human diseases, but achieving specificity has been highly challenging. A new approach of inhibiting the activation of the latent zymogen overcomes this obstacle. Shown are space-filling and ribbon crystal structures of proMMP-9 with a novel inhibitor unbound (left) and bound (right) and the resultant effects on a cellular invasion assay. For details, see the article by Scannevin et al., pages 17963–17974.

Editors' Picks Highlights

Editors' Picks

Classics

Cell Biology

Developmental Biology

Enzymology

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Protein Structure and Folding

RNA

Signal Transduction

Additions and Corrections

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