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December 2016

Volume 291Issue 53p1-27434
Open Access
On The Cover: Non-homologous end joining (NHEJ) complex is presented as a multiprotein machine that can be assembled in different ways and is flexibly linked to allow access for DNA double-strand break (DSB) repair. Ku (top) can bind to DSB ends (red) within the XRCC4/XLF assembly (bottom), stabilized through the interaction of a disordered APLF (right bottom) with Ku and XRCC4, while DNA ligase IV (left) and DNA-PKcs (right) are also linked into the core NHEJ machinery through flexible or disordered regions. For details see the article by Hammel et al., pages 26987–27006....
On The Cover: Non-homologous end joining (NHEJ) complex is presented as a multiprotein machine that can be assembled in different ways and is flexibly linked to allow access for DNA double-strand break (DSB) repair. Ku (top) can bind to DSB ends (red) within the XRCC4/XLF assembly (bottom), stabilized through the interaction of a disordered APLF (right bottom) with Ku and XRCC4, while DNA ligase IV (left) and DNA-PKcs (right) are also linked into the core NHEJ machinery through flexible or disordered regions. For details see the article by Hammel et al., pages 26987–27006.

Papers of the Week

Cell Biology

Developmental Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Immunology

Lipids

Metabolism

Microbiology

Molecular Bases of Disease

Neurobiology

Plant Biology

Protein Structure and Folding

RNA

Signal Transduction

Additions and Corrections

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