December 2016
Volume 291Issue 53p1-27434
Open Access
On The Cover: Non-homologous end joining (NHEJ) complex is presented as a multiprotein machine
that can be assembled in different ways and is flexibly linked to allow access for
DNA double-strand break (DSB) repair. Ku (top) can bind to DSB ends (red) within the XRCC4/XLF assembly (bottom), stabilized through the interaction of a disordered APLF (right bottom) with Ku and XRCC4, while DNA ligase IV (left) and DNA-PKcs (right) are also linked into the core NHEJ machinery through flexible or disordered regions.
For details see the article by Hammel et al., pages 26987–27006....Show more
On The Cover: Non-homologous end joining (NHEJ) complex is presented as a multiprotein machine
that can be assembled in different ways and is flexibly linked to allow access for
DNA double-strand break (DSB) repair. Ku (top) can bind to DSB ends (red) within the XRCC4/XLF assembly (bottom), stabilized through the interaction of a disordered APLF (right bottom) with Ku and XRCC4, while DNA ligase IV (left) and DNA-PKcs (right) are also linked into the core NHEJ machinery through flexible or disordered regions.
For details see the article by Hammel et al., pages 26987–27006.
