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June 19, 2015

Volume 290Issue 25p15362-15903
Open Access
On The Cover: Theoretical structure of a heparin dodecasaccharide fragment (Corey-Pauling-Koltun (CPK) representation) in complex with a dimer of chemokine CCL5 (ribbons and surface). Key amino acid residues that comprise the positively charged “RKNR” motif (green) interact with the negatively charged sulfate residues (orange). The binding mode, as determined through molecular dynamics (MD) simulation, indicates that heparin engages the binding motifs from both chains of the protein dimer. The image was prepared by Arunima Singh, CCRC, University of Georgia, using UCSF Chimera and GIMP. For details see the article by Singh et al., pages 15421–15436....
On The Cover: Theoretical structure of a heparin dodecasaccharide fragment (Corey-Pauling-Koltun (CPK) representation) in complex with a dimer of chemokine CCL5 (ribbons and surface). Key amino acid residues that comprise the positively charged “RKNR” motif (green) interact with the negatively charged sulfate residues (orange). The binding mode, as determined through molecular dynamics (MD) simulation, indicates that heparin engages the binding motifs from both chains of the protein dimer. The image was prepared by Arunima Singh, CCRC, University of Georgia, using UCSF Chimera and GIMP. For details see the article by Singh et al., pages 15421–15436.

Papers of the Week

Minireviews

Cell Biology

Computational Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Membrane Biology

Metabolism

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Plant Biology

Protein Structure and Folding

Protein Synthesis and Degradation

RNA

Signal Transduction

Additions and Corrections

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