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May 2018

Volume 293Issue 20p7488-7906
Open Access
On The Cover: The mechanism by which major histocompatibility complex (MHC) class I–bound peptides are trimmed by endoplasmic reticulum aminopeptidase 1 (ERAP1) is unknown. Here, we show that ERAP1 (upper structure) is able to access the peptide for trimming due to the partial dissociation of the N terminus of the MHC class I–bound peptide (lower structure). For details, see the article by Papakyriakou et al., pages 7538–7548....
On The Cover: The mechanism by which major histocompatibility complex (MHC) class I–bound peptides are trimmed by endoplasmic reticulum aminopeptidase 1 (ERAP1) is unknown. Here, we show that ERAP1 (upper structure) is able to access the peptide for trimming due to the partial dissociation of the N terminus of the MHC class I–bound peptide (lower structure). For details, see the article by Papakyriakou et al., pages 7538–7548.

Thematic Minireviews

Immunology

Molecular Bases of Disease

Lipids

Immunology

Microbiology

Molecular Bases of Disease

Signal Transduction

Cell Biology

Glycobiology and Extracellular Matrices

Protein Structure and Folding

Neurobiology

Microbiology

Molecular Bases of Disease

Signal Transduction

Protein Structure and Folding

Bioenergetics

Enzymology

Membrane Biology

Microbiology

DNA and Chromosomes

Molecular Bases of Disease

Enzymology

Membrane Biology

Cell Biology

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