Advertisement

March 30, 2018

Volume 293Issue 13p4591-4954
Open Access
On The Cover: An intramembrane aspartyl protease cleaving a substrate within the lipid membrane. Despite its broad biomedical reach, chemical details of peptide bond cleavage within the lipid membrane remain an enigma. In this study, we probe the interplay between positional and amino acid preferences for a model intramembrane aspartyl protease acting on different substrates. Photo credit: Oak Ridge National Laboratory/Jill Hemman. For details, see the article by Naing et al., pages 4653–4663....
On The Cover: An intramembrane aspartyl protease cleaving a substrate within the lipid membrane. Despite its broad biomedical reach, chemical details of peptide bond cleavage within the lipid membrane remain an enigma. In this study, we probe the interplay between positional and amino acid preferences for a model intramembrane aspartyl protease acting on different substrates. Photo credit: Oak Ridge National Laboratory/Jill Hemman. For details, see the article by Naing et al., pages 4653–4663.

Editors' Picks Highlights

Editors' Picks

Minireviews

Bioenergetics

Cell Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Immunology

Membrane Biology

Metabolism

Methods and Resources

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Protein Synthesis and Degradation

Signal Transduction

Additions and Corrections

Expressions of Concern

Withdrawals/Retractions

Advertisement