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August 04, 2017

Volume 292Issue 31p12725-13086
Open Access
On The Cover: The Kiss: Human peripheral blood monocytes challenged with lipopolysaccharide to promote the activation of the dimeric transcription factor NF-κB from Toll-like receptor 4 (TLR4). Treatment with glycerophosphoinositol compromises the signaling from TLR4, causing a delay in the lipopolysaccharide-induced NF-κB nuclear translocation. Representative confocal microscopy images of fixed monocytes stained for highlighting actin cytoskeleton (cyan blue), p65 protein (the subunit forming the canonical NF-κB heterodimer: p65-p50) (yellow), and chromatin (red) are shown. For details see the article by Vessichelli et al., pages 12828–12841....
On The Cover: The Kiss: Human peripheral blood monocytes challenged with lipopolysaccharide to promote the activation of the dimeric transcription factor NF-κB from Toll-like receptor 4 (TLR4). Treatment with glycerophosphoinositol compromises the signaling from TLR4, causing a delay in the lipopolysaccharide-induced NF-κB nuclear translocation. Representative confocal microscopy images of fixed monocytes stained for highlighting actin cytoskeleton (cyan blue), p65 protein (the subunit forming the canonical NF-κB heterodimer: p65-p50) (yellow), and chromatin (red) are shown. For details see the article by Vessichelli et al., pages 12828–12841.

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Bioenergetics

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DNA and Chromosomes

Enzymology

Lipids

Membrane Biology

Metabolism

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Molecular Bases of Disease

Plant Biology

Protein Structure and Folding

Protein Synthesis and Degradation

Signal Transduction

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