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April 06, 2018

Volume 293Issue 14p4955-5376
Open Access
On The Cover: Monoclonal antibodies have potential as future therapeutics for treatment of multidrug-resistant microbial infections. Shown is the Fab structure of the human antibody F598 in complex with a microbial polysaccharide poly-N-acetylglucosamine (PNAG), overlaid on an immunofluorescence image of F598 Fab–binding PNAG in Staphylococcus aureus biofilms. High resolution details of F598–PNAG interactions unravel the structural basis for antibody-based targeting of multiple microbial pathogens. For details, see the article by Soliman et al., pages 5079–5089....
On The Cover: Monoclonal antibodies have potential as future therapeutics for treatment of multidrug-resistant microbial infections. Shown is the Fab structure of the human antibody F598 in complex with a microbial polysaccharide poly-N-acetylglucosamine (PNAG), overlaid on an immunofluorescence image of F598 Fab–binding PNAG in Staphylococcus aureus biofilms. High resolution details of F598–PNAG interactions unravel the structural basis for antibody-based targeting of multiple microbial pathogens. For details, see the article by Soliman et al., pages 5079–5089.

Editors' Picks Highlights

Editors' Picks

Thematic Minireviews

Letters to the Editor

Cell Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Metabolism

Methods and Resources

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Protein Structure and Folding

Protein Synthesis and Degradation

Signal Transduction

Additions and Corrections

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