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August 07, 2015

Volume 290Issue 32p19387-20008
Open Access
On The Cover: Dopaminergic neurons in the substantia nigra are particularly vulnerable to neurodegeneration and aggregation of the protein α-synuclein in Parkinson disease. We found that small molecule LRRK2 kinase inhibitors can prevent much of the neurodegeneration associated with abnormal α-synuclein. Shown is a confocal image from the rat substantia nigra with abnormal nitrosylated/oxidized α-synuclein in red, activated microglia in blue, and tyrosine hydroxylase in green. For details see the article by Daher et al., pages 19433–19444....
On The Cover: Dopaminergic neurons in the substantia nigra are particularly vulnerable to neurodegeneration and aggregation of the protein α-synuclein in Parkinson disease. We found that small molecule LRRK2 kinase inhibitors can prevent much of the neurodegeneration associated with abnormal α-synuclein. Shown is a confocal image from the rat substantia nigra with abnormal nitrosylated/oxidized α-synuclein in red, activated microglia in blue, and tyrosine hydroxylase in green. For details see the article by Daher et al., pages 19433–19444.

Papers of the Week

Minireviews

Cell Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Genomics and Proteomics

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Protein Structure and Folding

Signal Transduction

Additions and Corrections

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