April 17, 2015

Editorial Board
Published in issue: April 17, 2015
i-iii

Author Index
Published in issue: April 17, 2015
vii-viii

Papers of the Week

Quantitative Analysis of the Activation of a Receptor Tyrosine Kinase♦
Quantitative Analysis of Receptor Tyrosine Kinase-Effector Coupling at Functionally Relevant Stimulus Levels
Published in issue: April 17, 2015
p10037

Minireviews

Systemic Amyloidosis: Lessons from β₂-Microglobulin*
• Monica Stoppini,
• Vittorio Bellotti
Published in issue: April 17, 2015
p9951-9958

Reports

Heterotrimeric G Proteins Directly Regulate MMP14/Membrane Type-1 Matrix Metalloprotease
A NOVEL MECHANISM FOR GPCR-EGFR TRANSACTIVATION *
• Aaron C. Overland,
• Paul A. Insel
Published in issue: April 17, 2015
p9941-9947

Letters to the Editor

Interleukin-2-inducible T-cell Kinase (ITK) Targeting by BMS-509744 Does Not Affect Cell Viability in T-cell Prolymphocytic Leukemia (T-PLL)
• Sabine Dondorf,
• Alexandra Schrader,
• Marco Herling
Published in issue: April 17, 2015
p10568-10569
Is Nitric Oxide Really the Primary Mediator of Pancreatic β-Cell Death in Type 1 Diabetes?
• Ewa Gurgul-Convey,
• Sigurd Lenzen
Published in issue: April 17, 2015
p10570
Reply to Gurgul-Convey and Lenzen: Cytokines, Nitric Oxide, and β-Cells
• Katarzyna A. Broniowska,
• Clayton E. Mathews,
• John A. Corbett
Published in issue: April 17, 2015
p10571

Cell Biology

The Pivotal Role of the Mitochondrial Amidoxime Reducing Component 2 in Protecting Human Cells against Apoptotic Effects of the Base Analog N⁶-Hydroxylaminopurine*
• Birte Plitzko,
• Antje Havemeyer,
• Thomas Kunze,
• Bernd Clement
Published in issue: April 17, 2015
p10126-10135

Mdm2 Promotes Myogenesis through the Ubiquitination and Degradation of CCAAT/Enhancer-binding Protein β
• Dechen Fu,
• Neena Lala-Tabbert,
• Hwabin Lee,
• Nadine Wiper-Bergeron
Published in issue: April 17, 2015
p10200-10207

Processivity of the Kinesin-2 KIF3A Results from Rear Head Gating and Not Front Head Gating*
• Geng-Yuan Chen,
• David F.J. Arginteanu,
• William O. Hancock
Published in issue: April 17, 2015
p10274-10294

Developmental Biology

Obstructor A Organizes Matrix Assembly at the Apical Cell Surface to Promote Enzymatic Cuticle Maturation in Drosophila*
• Yanina-Yasmin Pesch,
• Dietmar Riedel,
• Matthias Behr
Published in issue: April 17, 2015
p10071-10082

Zebrafish foxc1a Plays a Crucial Role in Early Somitogenesis by Restricting the Expression of aldh1a2 Directly*
• Jingyun Li,
• Yunyun Yue,
• Xiaohua Dong,
• ...
• Xiaoxi Nan,
• Qinxin Zhang,
• Qingshun Zhao
Published in issue: April 17, 2015
p10216-10228

DNA and Chromosomes

Influence of Oxidized Purine Processing on Strand Directionality of Mismatch Repair*
• Simone Repmann,
• Maite Olivera-Harris,
• Josef Jiricny
Published in issue: April 17, 2015
p9986-9999

Enzymology

Structure of Escherichia coli dGTP Triphosphohydrolase
A HEXAMERIC ENZYME WITH DNA EFFECTOR MOLECULES *
• Deepa Singh,
• Damian Gawel,
• Mark Itsko,
• ...
• Juno M. Krahn,
• Robert E. London,
• Roel M. Schaaper
Published in issue: April 17, 2015
p10418-10429

Gene Regulation

Alcohol Inhibits Osteopontin-dependent Transforming Growth Factor-β1 Expression in Human Mesenchymal Stem Cells
• Joseph Driver,
• Cynthia E. Weber,
• John J. Callaci,
• ...
• Mitchell F. Denning,
• Paul C. Kuo,
• Zhiyong Mi
Published in issue: April 17, 2015
p9959-9973

Coordinated Gene Regulation in the Initial Phase of Salt Stress Adaptation*
• Elena Vanacloig-Pedros,
• Carolina Bets-Plasencia,
• Amparo Pascual-Ahuir,
• Markus Proft
Published in issue: April 17, 2015
p10163-10175

Membrane and Integrative Nuclear Fibroblastic Growth Factor Receptor (FGFR) Regulation of FGF-23*
• Xiaobin Han,
• Zhousheng Xiao,
• L. Darryl Quarles
Published in issue: April 17, 2015
p10447-10459

Glycobiology and Extracellular Matrices

Neurons and Glia Modify Receptor Protein-tyrosine Phosphatase ζ (RPTPζ)/Phosphacan with Cell-specific O-Mannosyl Glycans in the Developing Brain*
• Chrissa A. Dwyer,
• Toshihiko Katoh,
• Michael Tiemeyer,
• Russell T. Matthews
Published in issue: April 17, 2015
p10256-10273

Immunology

Structural Basis for Penetration of the Glycan Shield of Hepatitis C Virus E2 Glycoprotein by a Broadly Neutralizing Human Antibody*
• Yili Li,
• Brian G. Pierce,
• Qian Wang,
• ...
• Thomas R. Fuerst,
• Steven K.H. Foung,
• Roy A. Mariuzza
Published in issue: April 17, 2015
p10117-10125

Specific Amyloid β Clearance by a Catalytic Antibody Construct*
• Stephanie A. Planque,
• Yasuhiro Nishiyama,
• Sari Sonoda,
• ...
• Brian O'Nuallain,
• Einar M. Sigurdsson,
• Sudhir Paul
Published in issue: April 17, 2015
p10229-10241

The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4*
• Shoeib Moradi,
• Richard Berry,
• Phillip Pymm,
• ...
• Andrew G. Brooks,
• Jamie Rossjohn,
• Julian P. Vivian
Published in issue: April 17, 2015
p10460-10471

Lipids

Substrate Efflux Propensity Is the Key Determinant of Ca²⁺-independent Phospholipase A-β (iPLAβ)-mediated Glycerophospholipid Hydrolysis*
• Krishna Chaithanya Batchu,
• Kati Hokynar,
• Michael Jeltsch,
• Kenny Mattonet,
• Pentti Somerharju
Published in issue: April 17, 2015
p10093-10103

Metabolism

Endoplasmic Reticulum (ER) Localization Is Critical for DsbA-L Protein to Suppress ER Stress and Adiponectin Down-regulation in Adipocytes*
• Meilian Liu,
• Hongzhi Chen,
• Li Wei,
• ...
• Weiping Jia,
• Lily Q. Dong,
• Feng Liu
Published in issue: April 17, 2015
p10143-10148

Strategies for Correcting Very Long Chain Acyl-CoA Dehydrogenase Deficiency*
• Margarita Tenopoulou,
• Jie Chen,
• Jean Bastin,
• Michael J. Bennett,
• Harry Ischiropoulos,
• Paschalis-Thomas Doulias
Published in issue: April 17, 2015
p10486-10494

Microbiology

Shu1 Is a Cell-surface Protein Involved in Iron Acquisition from Heme in Schizosaccharomyces pombe*
• Thierry Mourer,
• Jean-François Jacques,
• Ariane Brault,
• Martin Bisaillon,
• Simon Labbé
Published in issue: April 17, 2015
p10176-10190

Identification of a Novel HIV-1 Inhibitor Targeting Vif-dependent Degradation of Human APOBEC3G Protein*
• Erez Pery,
• Ann Sheehy,
• N. Miranda Nebane,
• ...
• E. Lucile White,
• Roger G. Ptak,
• Dana Gabuzda
Published in issue: April 17, 2015
p10504-10517

Molecular Bases of Disease

Nitric Oxide Induction of Parkin Translocation in PTEN-induced Putative Kinase 1 (PINK1) Deficiency
FUNCTIONAL ROLE OF NEURONAL NITRIC OXIDE SYNTHASE DURING MITOPHAGY *
• Ji-Young Han,
• Min-Ji Kang,
• Kyung-Hee Kim,
• ...
• Hyun-Seok Kim,
• Ji-Young Ha,
• Jin H. Son
Published in issue: April 17, 2015
p10325-10335

MicroRNA-31 Is a Transcriptional Target of Histone Deacetylase Inhibitors and a Regulator of Cellular Senescence*
• Joon-Ho Cho,
• Manjari Dimri,
• Goberdhan P. Dimri
Published in issue: April 17, 2015
p10555-10567

Molecular Biophysics

Multiple Driving Forces Required for Efficient Secretion of Autotransporter Virulence Proteins*
• Igor Drobnak,
• Esther Braselmann,
• Patricia L. Clark
Published in issue: April 17, 2015
p10104-10116

Oligomerization of the Polycystin-2 C-terminal Tail and Effects on Its Ca²⁺-binding Properties*
• Yifei Yang,
• Camille Keeler,
• Ivana Y. Kuo,
• Elias J. Lolis,
• Barbara E. Ehrlich,
• Michael E. Hodsdon
Published in issue: April 17, 2015
p10544-10554

Neurobiology

The Guanine Nucleotide Exchange Factor (GEF) Asef2 Promotes Dendritic Spine Formation via Rac Activation and Spinophilin-dependent Targeting*
• J. Corey Evans,
• Cristina M. Robinson,
• Mingjian Shi,
• Donna J. Webb
Published in issue: April 17, 2015
p10295-10308

Munc18a Does Not Alter Fusion Rates Mediated by Neuronal SNAREs, Synaptotagmin, and Complexin*
• Yunxiang Zhang,
• Jiajie Diao,
• Karen N. Colbert,
• ...
• Niket Shah,
• William I. Weis,
• Axel T. Brunger
Published in issue: April 17, 2015
p10518-10534

Synaptotagmin-1 Is an Antagonist for Munc18-1 in SNARE Zippering*
• Xiaochu Lou,
• Jaeil Shin,
• Yoosoo Yang,
• Jaewook Kim,
• Yeon-Kyun Shin
Published in issue: April 17, 2015
p10535-10543

Plant Biology

A Conserved Glutamate Residue in the C-terminal Deaminase Domain of Pentatricopeptide Repeat Proteins Is Required for RNA Editing Activity*
• Michael L. Hayes,
• Kim N. Dang,
• Michael F. Diaz,
• R. Michael Mulligan
Published in issue: April 17, 2015
p10136-10142

Protein Structure and Folding

Analysis of Cytochrome P450 CYP119 Ligand-dependent Conformational Dynamics by Two-dimensional NMR and X-ray Crystallography*
• Debashree Basudhar,
• Yarrow Madrona,
• Sylvie Kandel,
• Jed N. Lampe,
• Clinton R. Nishida,
• Paul R. Ortiz de Montellano
Published in issue: April 17, 2015
p10000-10017

Conformational Changes Leading to T7 DNA Delivery upon Interaction with the Bacterial Receptor*
• Verónica A. González-García,
• Mar Pulido-Cid,
• Carmela Garcia-Doval,
• ...
• Jaime Martín-Benito,
• Ana Cuervo,
• José L. Carrascosa
Published in issue: April 17, 2015
p10038-10044

Conformational Flexibility and Subunit Arrangement of the Modular Yeast Spt-Ada-Gcn5 Acetyltransferase Complex*
• Dheva Setiaputra,
• James D. Ross,
• Shan Lu,
• Derrick T. Cheng,
• Meng-Qiu Dong,
• Calvin K. Yip
Published in issue: April 17, 2015
p10057-10070

Modulation of the Chaperone DnaK Allosterism by the Nucleotide Exchange Factor GrpE*
• Roberto Melero,
• Fernando Moro,
• María Ángeles Pérez-Calvo,
• ...
• Oscar Llorca,
• Arturo Muga,
• José María Valpuesta
Published in issue: April 17, 2015
p10083-10092

Drosophila melanogaster Mini Spindles TOG3 Utilizes Unique Structural Elements to Promote Domain Stability and Maintain a TOG1- and TOG2-like Tubulin-binding Surface*
• Amy E. Howard,
• Jaime C. Fox,
• Kevin C. Slep
Published in issue: April 17, 2015
p10149-10162

A Globin Domain in a Neuronal Transmembrane Receptor of Caenorhabditis elegans and Ascaris suum
MOLECULAR MODELING AND FUNCTIONAL PROPERTIES *
• Lesley Tilleman,
• Francesca Germani,
• Sasha De Henau,
• ...
• Luc Moens,
• Angela Fago,
• Sylvia Dewilde
Published in issue: April 17, 2015
p10336-10352

A Triple Mutant in the Ω-loop of TEM-1 β-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis*
• Vlatko Stojanoski,
• Dar-Chone Chow,
• Liya Hu,
• ...
• Hiram F. Gilbert,
• B. V. Venkataram Prasad,
• Timothy Palzkill
Published in issue: April 17, 2015
p10382-10394

Structural Analysis of a Specialized Type III Secretion System Peptidoglycan-cleaving Enzyme*
• Brianne J. Burkinshaw,
• Wanyin Deng,
• Emilie Lameignère,
• ...
• Liam J. Worrall,
• B. Brett Finlay,
• Natalie C.J. Strynadka
Published in issue: April 17, 2015
p10406-10417

Protein Synthesis and Degradation

Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) Stability Contributes to YM155 Resistance in Human Gastric Cancer Cells*
• Soo-A Jung,
• Yong-Man Park,
• Seung-Woo Hong,
• ...
• Jung Shin Lee,
• Dong-Hoon Jin,
• TaeWon Kim
Published in issue: April 17, 2015
p9974-9985

Exploration of the Arrest Peptide Sequence Space Reveals Arrest-enhanced Variants*
• Florian Cymer,
• Rickard Hedman,
• Nurzian Ismail,
• Gunnar von Heijne
Published in issue: April 17, 2015
p10208-10215

Regulation of GATA-binding Protein 2 Levels via Ubiquitin-dependent Degradation by Fbw7
INVOLVEMENT OF CYCLIN B-CYCLIN-DEPENDENT KINASE 1-MEDIATED PHOSPHORYLATION OF THR¹⁷⁶ IN GATA-BINDING PROTEIN 2 *
• Tomomi Nakajima,
• Kyoko Kitagawa,
• Tatsuya Ohhata,
• ...
• Fuminori Katou,
• Hiroyuki Niida,
• Masatoshi Kitagawa
Published in issue: April 17, 2015
p10368-10381

RNA

Ancestral AlaX Editing Enzymes for Control of Genetic Code Fidelity Are Not tRNA-specific*
• Eva Maria Novoa,
• Oscar Vargas-Rodriguez,
• Stefanie Lange,
• ...
• Hiroaki Suga,
• Karin Musier-Forsyth,
• Lluís Ribas de Pouplana
Published in issue: April 17, 2015
p10495-10503

Signal Transduction

Quantitative Analysis of Receptor Tyrosine Kinase-Effector Coupling at Functionally Relevant Stimulus Levels*^♦
• Simin Li,
• Devayani Bhave,
• Jennifer M. Chow,
• ...
• Mariya Atanasova,
• Richard L. Cate,
• Adrian Whitty
Published in issue: April 17, 2015
p10018-10036

Activation of Microtubule Dynamics Increases Neuronal Growth via the Nerve Growth Factor (NGF)- and Gα_s-mediated Signaling Pathways*
• Tulika Sarma,
• Athanasia Koutsouris,
• Jiang Zhu Yu,
• Aleksandar Krbanjevic,
• Thomas J. Hope,
• Mark M. Rasenick
Published in issue: April 17, 2015
p10045-10056

Type I Interferon Controls Propagation of Long Interspersed Element-1*
• Qiujing Yu,
• Christopher J. Carbone,
• Yuliya V. Katlinskaya,
• ...
• P. Jeremy Wang,
• Roger A. Greenberg,
• Serge Y. Fuchs
Published in issue: April 17, 2015
p10191-10199

Targeted Ablation of the Pde6h Gene in Mice Reveals Cross-species Differences in Cone and Rod Phototransduction Protein Isoform Inventory*
• Christina Brennenstuhl,
• Naoyuki Tanimoto,
• Markus Burkard,
• ...
• Peter Ruth,
• Bernd Wissinger,
• Robert Lukowski
Published in issue: April 17, 2015
p10242-10255

Activation of Peroxisome Proliferator-activated Receptor α Induces Lysosomal Biogenesis in Brain Cells
IMPLICATIONS FOR LYSOSOMAL STORAGE DISORDERS *
• Arunava Ghosh,
• Malabendu Jana,
• Khushbu Modi,
• ...
• Katherine B. Sims,
• Elizabeth Berry-Kravis,
• Kalipada Pahan
Published in issue: April 17, 2015
p10309-10324

Signaling Pathways That Control Rho Kinase Activity Maintain the Embryonic Epicardial Progenitor State
• Mykhaylo V. Artamonov,
• Li Jin,
• Aaron S. Franke,
• ...
• Xiu Rong Dong,
• Mark W. Majesky,
• Avril V. Somlyo
Published in issue: April 17, 2015
p10353-10367

Ubiquitin-associated Domain-containing Ubiquitin Regulatory X (UBX) Protein UBXN1 Is a Negative Regulator of Nuclear Factor κB (NF-κB) Signaling*
• Yu-Bo Wang,
• Bo Tan,
• Rui Mu,
• ...
• Ai-Ling Li,
• Xue-Min Zhang,
• Hui-Yan Li
Published in issue: April 17, 2015
p10395-10405

Sul1 and Sul2 Sulfate Transceptors Signal to Protein Kinase A upon Exit of Sulfur Starvation*
• Harish Nag Kankipati,
• Marta Rubio-Texeira,
• Dries Castermans,
• George Diallinas,
• Johan M. Thevelein
Published in issue: April 17, 2015
p10430-10446

PKD1 Protein Is Involved in Reactive Oxygen Species-mediated Mitochondrial Depolarization in Cooperation with Protein Kinase Cδ (PKCδ)*
• Thianzhou Zhang,
• Philip Sell,
• Ursula Braun,
• Michael Leitges
Published in issue: April 17, 2015
p10472-10485

Additions and Corrections

Nuclear import of the U1A splicesome protein is mediated by importin α/β and Ran in living mammalian cells.
• Miki Hieda,
• Taro Tachibana,
• Masahiro Fukumoto,
• Yoshihiro Yoneda
Published in issue: April 17, 2015
p9948
Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation.
• Yunbo Qiao,
• Ran Wang,
• Xianfa Yang,
• Ke Tang,
• Naihe Jing
Published in issue: April 17, 2015
p9949
HdeB functions as an acid-protective chaperone in bacteria.
• Jan-Ulrik Dahl,
• Philipp Koldewey,
• Loïc Salmon,
• Scott Horowitz,
• James C.A. Bardwell,
• Ursula Jakob
Published in issue: April 17, 2015
p9950