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February 21, 2014

Volume 289Issue 8p4546-5347
Open Access
On The Cover: Image is a 4-stranded interwoven braid representing 4 RNA molecules forming a G-quadruplex, the molecular structure at bottom right. RNA is the amyotrophic lateral sclerosis (ALS)-associated C9orf72 genetic sequence, r(GGGGCC)n. In this issue, Zamiri et al., pages 4653–4659, show that this RNA forms a G-quadruplex that binds RNA-binding proteins, which may be an important factor in ALS, particularly with regard to the RNA foci observed in patient cells. Protein interactions can be disrupted by interaction with the G-quadruplex-specific porphyrin TMPyP4, which has potential therapeutic implications. Image conception and production by C. E. Pearson, N. T. Pearson, and D. Dubins....
On The Cover: Image is a 4-stranded interwoven braid representing 4 RNA molecules forming a G-quadruplex, the molecular structure at bottom right. RNA is the amyotrophic lateral sclerosis (ALS)-associated C9orf72 genetic sequence, r(GGGGCC)n. In this issue, Zamiri et al., pages 4653–4659, show that this RNA forms a G-quadruplex that binds RNA-binding proteins, which may be an important factor in ALS, particularly with regard to the RNA foci observed in patient cells. Protein interactions can be disrupted by interaction with the G-quadruplex-specific porphyrin TMPyP4, which has potential therapeutic implications. Image conception and production by C. E. Pearson, N. T. Pearson, and D. Dubins.

Papers of the week

Minireviews

Reports

Bioenergetics

Cell Biology

Developmental Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Metabolism

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Protein Structure and Folding

Protein Synthesis and Degradation

Signal Transduction

Additions and Corrections

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