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October 29, 2010

Volume 285Issue 44p33577-34298
Open Access
On The Cover: Phosphatidyl-myo-inositol mannosides (PIMs) are key glycolipids of the mycobacterial cell envelope. They are considered not only essential structural components of the cell but also important molecules implicated in host-pathogen interactions. The crystal structure of PimA, a key component of this biosynthetic machinery, has been solved recently. This is the very first crystal structure of a glycosyltransferase involved in mycobacterial cell wall biosynthesis. The image illustrates the GT-B fold adopted by PimA (cyan) and a selected region of the crystal packing (orange). For details, see the article by Guerin et al., pages 33577–33583....
On The Cover: Phosphatidyl-myo-inositol mannosides (PIMs) are key glycolipids of the mycobacterial cell envelope. They are considered not only essential structural components of the cell but also important molecules implicated in host-pathogen interactions. The crystal structure of PimA, a key component of this biosynthetic machinery, has been solved recently. This is the very first crystal structure of a glycosyltransferase involved in mycobacterial cell wall biosynthesis. The image illustrates the GT-B fold adopted by PimA (cyan) and a selected region of the crystal packing (orange). For details, see the article by Guerin et al., pages 33577–33583.

Papers of the Week

Minireviews

Reports

Classics

Cell Biology

Developmental Biology

Enzymology

Gene Regulation

Genomics and Proteomics

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

Neurobiology

Protein Structure and Folding

Protein Synthesis and Degradation

RNA

Signal Transduction

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