Table of Contents page: Journal of Biological Chemistry

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Editorial Board

Published online: October 25, 2013

i-iii

Author Index

Published online: October 25, 2013

viii-ix

A Yeast Protein's Chaperone Activity Becomes Critical during Zinc Deficiency♦

Published online: October 25, 2013

p31328

Role of Tyrosine Phosphorylation in Intermediate Filament Protein Organization♦

Published online: October 25, 2013

p31338

SIRT6's Histone Deacetylase Activity Is Triggered by Free Fatty Acids♦

Published online: October 25, 2013

p31357

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins*^♦

Jessica L. Feldman,
Josue Baeza,
John M. Denu

Published online: September 18, 2013

p31350-31356

Aspartic Acid 397 in Subunit B of the Na⁺-pumping NADH:Quinone Oxidoreductase from Vibrio cholerae Forms Part of a Sodium-binding Site, Is Involved in Cation Selectivity, and Affects Cation-binding Site Cooperativity

Michael E. Shea,
Oscar Juárez,
Jonathan Cho,
Blanca Barquera

Published online: September 12, 2013

p31241-31249

miR-1247 Functions by Targeting Cartilage Transcription Factor SOX9*

Aida Martinez-Sanchez,
Chris L. Murphy

Published online: September 06, 2013

p30802-30814

The Rho Family Member RhoE Interacts with Skp2 and Is Degraded at the Proteasome during Cell Cycle Progression*

Marta Lonjedo,
Enric Poch,
Enric Mocholí,
...
Thomas F. Franke,
Rosa M. Guasch,
Ignacio Pérez-Roger

Published online: September 17, 2013

p30872-30882

The Functional Interaction of Mitochondrial Hsp70s with the Escort Protein Zim17 Is Critical for Fe/S Biogenesis and Substrate Interaction at the Inner Membrane Preprotein Translocase*

Ilka Lewrenz,
Nicole Rietzschel,
Bernard Guiard,
Roland Lill,
Martin van der Laan,
Wolfgang Voos

Published online: September 12, 2013

p30931-30943

Hepatocyte Nuclear Factor 6 Suppresses the Migration and Invasive Growth of Lung Cancer Cells through p53 and the Inhibition of Epithelial-Mesenchymal Transition*

Xin-Wang Yuan,
Dong-Mei Wang,
Ying Hu,
...
Wei-Wei Shi,
Xiao-Jie Guo,
Jian-Guo Song

Published online: September 10, 2013

p31206-31216

Phosphorylation and mRNA Splicing of Collapsin Response Mediator Protein-2 Determine Inhibition of Rho-associated Protein Kinase (ROCK) II Function in Carcinoma Cell Migration and Invasion*

Marie Morgan-Fisher,
John R. Couchman,
Atsuko Yoneda

Published online: September 13, 2013

p31229-31240

The Paired-box Homeodomain Transcription Factor Pax6 Binds to the Upstream Region of the TRAP Gene Promoter and Suppresses Receptor Activator of NF-κB Ligand (RANKL)-induced Osteoclast Differentiation*

Masakazu Kogawa,
Koji Hisatake,
Gerald J. Atkins,
...
Tatsuo Suda,
Yasushi Okazaki,
Masahito Matsumoto

Published online: August 29, 2013

p31299-31312

Peroxiredoxin Chaperone Activity Is Critical for Protein Homeostasis in Zinc-deficient Yeast*^♦

Colin W. MacDiarmid,
Janet Taggart,
Kittikhun Kerdsomboon,
...
Supawee Panascharoen,
Katherine Schelble,
David J. Eide

Published online: September 10, 2013

p31313-31327

A Conserved Rod Domain Phosphotyrosine That Is Targeted by the Phosphatase PTP1B Promotes Keratin 8 Protein Insolubility and Filament Organization*^♦

Natasha T. Snider,
Haewon Park,
M. Bishr Omary

Published online: September 03, 2013

p31329-31337

Mitochondrial Ribosomal RNA (rRNA) Methyltransferase Family Members Are Positioned to Modify Nascent rRNA in Foci near the Mitochondrial DNA Nucleoid*

Ken-Wing Lee,
Cynthia Okot-Kotber,
Joseph F. LaComb,
Daniel F. Bogenhagen

Published online: September 13, 2013

p31386-31399

Autoinhibition and Signaling by the Switch II Motif in the G-protein Chaperone of a Radical B12 Enzyme*

Autoinhibition and Signaling by the Switch II Motif in the G-protein Chaperone of a Radical B₁₂ Enzyme*

Michael Lofgren,
Markos Koutmos,
Ruma Banerjee

Published online: August 30, 2013

p30980-30989

Histone H2A Ubiquitination Inhibits the Enzymatic Activity of H3 Lysine 36 Methyltransferases*

Gang Yuan,
Ben Ma,
Wen Yuan,
...
She Chen,
Guohong Li,
Bing Zhu

Published online: September 09, 2013

p30832-30842

The Ccr4-Not Protein Complex Regulates the Phase of the Neurospora Circadian Clock by Controlling WHITE COLLAR Protein Stability and Activity*

Guocun Huang,
Qiyang He,
Jinhu Guo,
Joonseok Cha,
Yi Liu

Published online: September 12, 2013

p31002-31009

Toxoplasma Transcription Factor TgAP2XI-5 Regulates the Expression of Genes Involved in Parasite Virulence and Host Invasion*

Robert Walker,
Mathieu Gissot,
Ludovic Huot,
...
Alain Van Dorsselaer,
Kami Kim,
Stanislas Tomavo

Published online: September 10, 2013

p31127-31138

Ei24, a Novel E2F Target Gene, Affects p53-independent Cell Death upon Ultraviolet C Irradiation*

Young Hoon Sung,
Young Jin,
Yunhwa Kang,
...
Jaehoon Lee,
Jae-il Roh,
Han-Woong Lee

Published online: September 06, 2013

p31261-31267

The Lutheran/Basal Cell Adhesion Molecule Promotes Tumor Cell Migration by Modulating Integrin-mediated Cell Attachment to Laminin-511 Protein*

Yamato Kikkawa,
Takaho Ogawa,
Ryo Sudo,
...
Kentaro Hozumi,
Motoyoshi Nomizu,
Jeffrey H. Miner

Published online: September 13, 2013

p30990-31001

Engineered Protease-resistant Antibodies with Selectable Cell-killing Functions*

Michelle Kinder,
Allison R. Greenplate,
Katharine D. Grugan,
...
Robert E. Jordan,
William R. Strohl,
Randall J. Brezski

Published online: August 28, 2013

p30843-30854

Glycoepitopes of Staphylococcal Wall Teichoic Acid Govern Complement-mediated Opsonophagocytosis via Human Serum Antibody and Mannose-binding Lectin*

Kenji Kurokawa,
Dong-Jun Jung,
Jang-Hyun An,
...
Hee-Ju Park,
Andreas Peschel,
Bok Luel Lee

Published online: September 17, 2013

p30956-30968

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL*

William J. Kaiser,
Haripriya Sridharan,
Chunzi Huang,
...
Robert W. Marquis,
John Bertin,
Edward S. Mocarski

Published online: September 09, 2013

p31268-31279

Protection of a Ceramide Synthase 2 Null Mouse from Drug-induced Liver Injury

Woo-Jae Park,
Joo-Won Park,
Racheli Erez-Roman,
...
Alfred H. Merrill Jr.,
Yael Pewzner-Jung,
Anthony H. Futerman

Published online: September 09, 2013

p30904-30916

Conformational Plasticity and Ligand Binding of Bacterial Monoacylglycerol Lipase*

Srinivasan Rengachari,
Philipp Aschauer,
Matthias Schittmayer,
...
Ruth Birner-Gruenberger,
Ingrid Dreveny,
Monika Oberer

Published online: September 06, 2013

p31093-31104

Conformational Changes Produced by ATP Binding to the Plasma Membrane Calcium Pump*

Irene C. Mangialavori,
Mariela S. Ferreira-Gomes,
Nicolás A. Saffioti,
Rodolfo M. González-Lebrero,
Rolando C. Rossi,
Juan Pablo F.C. Rossi

Published online: September 11, 2013

p31030-31041

CR1-mediated ATP Release by Human Red Blood Cells Promotes CR1 Clustering and Modulates the Immune Transfer Process*

Mark I. Melhorn,
Abigail S. Brodsky,
Jessica Estanislau,
...
Elena Dolmatova,
Heather S. Duffy,
Ionita C. Ghiran

Published online: September 10, 2013

p31139-31153

Identification of Novel Cholesterol-binding Regions in Kir2 Channels*

Avia Rosenhouse-Dantsker,
Sergei Noskov,
Serdar Durdagi,
Diomedes E. Logothetis,
Irena Levitan

Published online: September 09, 2013

p31154-31164

Mutations in SLC2A2 Gene Reveal hGLUT2 Function in Pancreatic β Cell Development*

Aurélien Michau,
Ghislaine Guillemain,
Alexandra Grosfeld,
...
Edith Brot-Laroche,
Armelle Leturque,
Maude Le Gall

Published online: August 28, 2013

p31080-31092

Insulin Activates RSK (p90 Ribosomal S6 Kinase) to Trigger a New Negative Feedback Loop That Regulates Insulin Signaling for Glucose Metabolism*

Nicolas Smadja-Lamère,
Michael Shum,
Paul Déléris,
Philippe P. Roux,
Jun-Ichi Abe,
André Marette

Published online: September 13, 2013

p31165-31176

Fatty Acid Labeling from Glutamine in Hypoxia Can Be Explained by Isotope Exchange without Net Reductive Isocitrate Dehydrogenase (IDH) Flux

Jing Fan,
Jurre J. Kamphorst,
Joshua D. Rabinowitz,
Tomer Shlomi

Published online: September 12, 2013

p31363-31369

Characterization of a Nodavirus Replicase Revealed a de Novo Initiation Mechanism of RNA Synthesis and Terminal Nucleotidyltransferase Activity*

Zhaowei Wang,
Yang Qiu,
Yongxiang Liu,
...
Di Wu,
Yuanyang Hu,
Xi Zhou

Published online: September 09, 2013

p30785-30801

A Non-classical Assembly Pathway of Escherichia coli Pore-forming Toxin Cytolysin A

Monifa Fahie,
Fabian B. Romano,
Christina Chisholm,
Alejandro P. Heuck,
Mark Zbinden,
Min Chen

Published online: September 09, 2013

p31042-31051

Disarming Bacterial Virulence through Chemical Inhibition of the DNA Binding Domain of an AraC-like Transcriptional Activator Protein*

Ji Yang,
Dianna M. Hocking,
Catherine Cheng,
...
Elizabeth L. Hartland,
Marija Tauschek,
Roy M. Robins-Browne

Published online: September 09, 2013

p31115-31126

Dual Positive Feedback Regulation of Protein Degradation of an Extra-cytoplasmic Function σ Factor for Cell Differentiation in *Streptomyces coelicolor**

Xu-Ming Mao,
旭明毛,
Ning Sun,
...
方亮黄,
Yong-Quan Li,
永泉李

Published online: September 06, 2013

p31217-31228

Structure, Folding Dynamics, and Amyloidogenesis of D76N β2-Microglobulin

Structure, Folding Dynamics, and Amyloidogenesis of D76N β₂-Microglobulin

P. Patrizia Mangione,
Gennaro Esposito,
Annalisa Relini,
...
Mark B. Pepys,
Monica Stoppini,
Vittorio Bellotti

Published online: September 06, 2013

p30917-30930

Endoplasmic Reticulum Oxidoreductin-1α (Ero1α) Improves Folding and Secretion of Mutant Proinsulin and Limits Mutant Proinsulin-induced Endoplasmic Reticulum Stress*

Jordan Wright,
Julia Birk,
Leena Haataja,
...
Michael A. Weiss,
Christian Appenzeller-Herzog,
Peter Arvan

Published online: September 10, 2013

p31010-31018

General Control Nonderepressible 2 (GCN2) Kinase Protects Oligodendrocytes and White Matter during Branched-chain Amino Acid Deficiency in Mice*

Pengxiang She,
Piyawan Bunpo,
Judy K. Cundiff,
Ronald C. Wek,
Robert A. Harris,
Tracy G. Anthony

Published online: September 09, 2013

p31250-31260

Two Sides of MGP Null Arterial Disease

Kelly E. Beazley,
Steven Reckard,
Dmitry Nurminsky,
Florence Lima,
Maria Nurminskaya

Published online: September 13, 2013

p31400-31408

The Power of Two

Lu Huo,
Ian Davis,
Lirong Chen,
Aimin Liu

Published online: September 09, 2013

p30862-30871

β-Adrenergic Receptors Activate Exchange Protein Directly Activated by cAMP (Epac), Translocate Munc13-1, and Enhance the Rab3A-RIM1α Interaction to Potentiate Glutamate Release at Cerebrocortical Nerve Terminals*

Jose J. Ferrero,
Ana M. Alvarez,
Jorge Ramírez-Franco,
...
Rafael Luján,
Francisco Ciruela,
José Sánchez-Prieto

Published online: September 13, 2013

p31370-31385

The Outer Membrane TolC-like Channel HgdD Is Part of Tripartite Resistance-Nodulation-Cell Division (RND) Efflux Systems Conferring Multiple-drug Resistance in the Cyanobacterium Anabaena sp. PCC7120*

Alexander Hahn,
Mara Stevanovic,
Oliver Mirus,
Iryna Lytvynenko,
Klaas Martinus Pos,
Enrico Schleiff

Published online: September 06, 2013

p31192-31205

Structural Basis of Mycobacterial Inhibition by Cyclomarin A

Dileep Vasudevan,
Srinivasa P.S. Rao,
Christian G. Noble

Published online: September 10, 2013

p30883-30891

Repetitive Protein Unfolding by the trans Ring of the GroEL-GroES Chaperonin Complex Stimulates Folding*

Zong Lin,
Jason Puchalla,
Daniel Shoup,
Hays S. Rye

Published online: September 10, 2013

p30944-30955

Complex Structure of the DNA-binding Domain of AdpA, the Global Transcription Factor in Streptomyces griseus, and a Target Duplex DNA Reveals the Structural Basis of Its Tolerant DNA Sequence Specificity*

Ming Dong Yao,
明東姚,
Jun Ohtsuka,
...
西康夫大,
Masaru Tanokura,
之倉優田

Published online: September 09, 2013

p31019-31029

A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation Activities*

Siew Pheng Lim,
Jolene Hong Kiew Koh,
Cheah Chen Seh,
...
Tobias C. Cornvik,
Pei-Yong Shi,
Julien Lescar

Published online: September 11, 2013

p31105-31114

Replacing the Factor VIII C1 Domain with a Second C2 Domain Reduces Factor VIII Stability and Affinity for Factor IXa*

Hironao Wakabayashi,
Philip J. Fay

Published online: September 12, 2013

p31289-31297

Novel Details of Calsequestrin Gel Conformation *in Situ**

Stefano Perni,
Matthew Close,
Clara Franzini-Armstrong

Published online: September 11, 2013

p31358-31362

Genetic Code-guided Protein Synthesis and Folding in *Escherichia coli**

Shaoliang Hu,
Mingrong Wang,
Guoping Cai,
Mingyue He

Published online: September 03, 2013

p30855-30861

Jun Activation Domain-binding Protein 1 (JAB1) Is Required for the Optimal Response to Interferons*

Ryuta Muromoto,
Maiko Nakajima,
Koki Hirashima,
...
Kazuya Shimoda,
Kenji Oritani,
Tadashi Matsuda

Published online: September 16, 2013

p30969-30979

Endoplasmic Reticulum Protein Quality Control Is Determined by Cooperative Interactions between Hsp/c70 Protein and the CHIP E3 Ligase*

Yoshihiro Matsumura,
Juro Sakai,
William R. Skach

Published online: August 29, 2013

p31069-31079

RNF185 Is a Novel E3 Ligase of Endoplasmic Reticulum-associated Degradation (ERAD) That Targets Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)*

Elma El Khouri,
Gwenaëlle Le Pavec,
Michel B. Toledano,
Agnès Delaunay-Moisan

Published online: September 09, 2013

p31177-31191

NEDD8 Ultimate Buster-1 Long (NUB1L) Protein Promotes Transfer of NEDD8 to Proteasome for Degradation through the P97^UFD1/NPL4 Complex*

Shuai Liu,
Hui Yang,
Jian Zhao,
Yu-Hang Zhang,
Ai-Xin Song,
Hong-Yu Hu

Published online: September 09, 2013

p31339-31349

Novel Role for p21-activated Kinase 2 in Thrombin-induced Monocyte Migration*

Ravisekhar Gadepalli,
Sivareddy Kotla,
Mark R. Heckle,
Shailendra K. Verma,
Nikhlesh K. Singh,
Gadiparthi N. Rao

Published online: September 11, 2013

p30815-30831

MUC1-C Oncoprotein Activates ERK→C/EBPβ Signaling and Induction of Aldehyde Dehydrogenase 1A1 in Breast Cancer Cells*

Maroof Alam,
Rehan Ahmad,
Hasan Rajabi,
Akriti Kharbanda,
Donald Kufe

Published online: September 16, 2013

p30892-30903

Ptc1 Protein Phosphatase 2C Contributes to Glucose Regulation of SNF1/AMP-activated Protein Kinase (AMPK) in *Saccharomyces cerevisiae**

Amparo Ruiz,
Xinjing Xu,
Marian Carlson

Published online: September 09, 2013

p31052-31058

p87 and p101 Subunits Are Distinct Regulators Determining Class I_B Phosphoinositide 3-Kinase (PI3K) Specificity*

Aliaksei Shymanets,
Prajwal,
Kirsten Bucher,
Sandra Beer-Hammer,
Christian Harteneck,
Bernd Nürnberg

Published online: September 06, 2013

p31059-31068

Mitochondrial Localized Stat3 Promotes Breast Cancer Growth via Phosphorylation of Serine 727*

Qifang Zhang,
Vidisha Raje,
Vasily A. Yakovlev,
...
Kristoffer Valerie,
Paul Dent,
Andrew C. Larner

Published online: September 09, 2013

p31280-31288

A novel function of Onecut1 protein as a negative regulator of MafA gene expression.

Kaoru Yamamoto,
Taka-aki Matsuoka,
Satoshi Kawashima,
...
Takeshi Miyatsuka,
Hideaki Kaneto,
Iichiro Shimomura

Published online: October 25, 2013

p31298

October 25, 2013

Papers of the Week

Peroxiredoxin Chaperone Activity Is Critical for Protein Homeostasis in Zinc-deficient Yeast

A Conserved Rod Domain Phosphotyrosine That Is Targeted by the Phosphatase PTP1B Promotes Keratin 8 Protein Insolubility and Filament Organization

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

Reports

Bioenergetics

Cell Biology

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Lipids

ROLE OF GAP JUNCTION DYSFUNCTION AND CONNEXIN 32 MISLOCALIZATION *

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

ROLES OF SHEAR FLOW, HYDROPHOBIC SURFACES, AND α-CRYSTALLIN *

CHONDROGENIC LESIONS DEPENDENT ON TRANSGLUTAMINASE 2 AND ELASTIN FRAGMENTATION ASSOCIATED WITH INDUCTION OF ADIPSIN *

Molecular Biophysics

ARGININE 51 AND ARGININE 239* FROM A NEIGHBORING SUBUNIT ARE ESSENTIAL FOR CATALYSIS IN α-AMINO-β-CARBOXYMUCONATE-ϵ-SEMIALDEHYDE DECARBOXYLASE *

Neurobiology

Plant Biology

Protein Structure and Folding

Protein Synthesis and Degradation

Signal Transduction

Additions and Corrections