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September 13, 2013

Volume 288Issue 37p26350-26968
Open Access
On The Cover: Stability of EGF receptor (EGFR) is regulated either by EGF-stimulated homo- or heterodimer formation (left side; EGF is shown in purple) or via intracellular interaction with Hsp90 (right side). A team from the University of Michigan led by Drs. Mukesh Nyati and Ted Lawrence has found that both of these interactions occur via the αC-β4 loop region of EGFR (marked orange in the right side of the figure). They further demonstrated that a small cell-permeable peptide “Disruptin” (shown in orange in the middle panel) can block both the EGFR dimerization and interaction with Hsp90, which induces EGFR degradation and cell death in EGFR-driven tumor cell lines. The paper published in this issue on pages 26879–26886 provides proof of concept for the development of a new class of anti-tumor drugs that specifically cause EGFR degradation. Illustration by Steven Kronenberg....
On The Cover: Stability of EGF receptor (EGFR) is regulated either by EGF-stimulated homo- or heterodimer formation (left side; EGF is shown in purple) or via intracellular interaction with Hsp90 (right side). A team from the University of Michigan led by Drs. Mukesh Nyati and Ted Lawrence has found that both of these interactions occur via the αC-β4 loop region of EGFR (marked orange in the right side of the figure). They further demonstrated that a small cell-permeable peptide “Disruptin” (shown in orange in the middle panel) can block both the EGFR dimerization and interaction with Hsp90, which induces EGFR degradation and cell death in EGFR-driven tumor cell lines. The paper published in this issue on pages 26879–26886 provides proof of concept for the development of a new class of anti-tumor drugs that specifically cause EGFR degradation. Illustration by Steven Kronenberg.

Papers of the Week

Minireviews

Letters to the Editor

Bioenergetics

Cell Biology

Computational Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Microbiology

Molecular Bases of Disease

Neurobiology

Plant Biology

Protein Structure and Folding

Protein Synthesis and Degradation

RNA

Signal Transduction

Additions and Corrections

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