June 03, 2011

Editorial Board
Published in issue: June 03, 2011
i-iii

Author Index
Published in issue: June 03, 2011
xiii-xiv

Papers of the Week

BP: Bacterial Petroleum?♦
Molybdenum Nitrogenase Catalyzes the Reduction and Coupling of CO to Form Hydrocarbons
Published in issue: June 03, 2011
e99942


Controlling Hyaluronan Synthase 2 Expression♦
The Human Hyaluronan Synthase 2 (HAS2) Gene and Its Natural Antisense RNA Exhibit Coordinated Expression in the Renal Proximal Tubular Epithelial Cell
Published in issue: June 03, 2011
e99943


Three Uses for Parkin♦
Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane
Published in issue: June 03, 2011
e99944

Bioenergetics

Restoration of Rapidly Reversible Photoprotective Energy Dissipation in the Absence of PsbS Protein by Enhanced ΔpH*
• Matthew P. Johnson,
• Alexander V. Ruban
Published in issue: June 03, 2011
p19973-19981

Cell Biology

Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein*
• Michel Bernier,
• Rajib K. Paul,
• Alejandro Martin-Montalvo,
• ...
• Yaping Zong,
• David A. Sinclair,
• Rafael de Cabo
Published in issue: June 03, 2011
p19270-19279

Formation of Stable Homomeric and Transient Heteromeric Bone Morphogenetic Protein (BMP) Receptor Complexes Regulates Smad Protein Signaling*
• Barak Marom,
• Eva Heining,
• Petra Knaus,
• Yoav I. Henis
Published in issue: June 03, 2011
p19287-19296

Rb1 Gene Inactivation Expands Satellite Cell and Postnatal Myoblast Pools*
• Tohru Hosoyama,
• Koichi Nishijo,
• Suresh I. Prajapati,
• Guangheng Li,
• Charles Keller
Published in issue: June 03, 2011
p19556-19564

Daxx-β and Daxx-γ, Two Novel Splice Variants of the Transcriptional Co-repressor Daxx*
• Nils Wethkamp,
• Helmut Hanenberg,
• Sarah Funke,
• ...
• Rainer Engers,
• Helmut E. Gabbert,
• Csaba Mahotka
Published in issue: June 03, 2011
p19576-19588

Ibulocydine Is a Novel Prodrug Cdk Inhibitor That Effectively Induces Apoptosis in Hepatocellular Carcinoma Cells*
• Seung-Ju Cho,
• Young-Jong Kim,
• Young-Joon Surh,
• B. Moon Kim,
• Seung-Ki Lee
Published in issue: June 03, 2011
p19662-19671

Identification of a Novel Muscle A-type Lamin-interacting Protein (MLIP)*
• Elmira Ahmady,
• Shelley A. Deeke,
• Seham Rabaa,
• ...
• Laura Kenney,
• Alexandre F.R. Stewart,
• Patrick G. Burgon
Published in issue: June 03, 2011
p19702-19713

Mammalian Polo-like Kinase 1-dependent Regulation of the PBIP1-CENP-Q Complex at Kinetochores*
• Young H. Kang,
• Chi Hoon Park,
• Tae-Sung Kim,
• ...
• Bo Y. Kim,
• Jung-Eun Park,
• Kyung S. Lee
Published in issue: June 03, 2011
p19744-19757

A Competitive Binding Mechanism between Skp1 and Exportin 1 (CRM1) Controls the Localization of a Subset of F-box Proteins*
• David E. Nelson,
• Heike Laman
Published in issue: June 03, 2011
p19804-19815

In Vivo Crystallization of Human IgG in the Endoplasmic Reticulum of Engineered Chinese Hamster Ovary (CHO) Cells
• Haruki Hasegawa,
• John Wendling,
• Feng He,
• ...
• Timothy Osslund,
• Min Shen,
• Randal R. Ketchem
Published in issue: June 03, 2011
p19917-19931

The Interferon-γ-induced GTPase, mGBP-2, Inhibits Tumor Necrosis Factor α (TNF-α) Induction of Matrix Metalloproteinase-9 (MMP-9) by Inhibiting NF-κB and Rac Protein*
• Sujata Balasubramanian,
• Meiyun Fan,
• Angela F. Messmer-Blust,
• ...
• Jonathan A. Jeyaratnam,
• Lawrence M. Pfeffer,
• Deborah J. Vestal
Published in issue: June 03, 2011
p20054-20064

Computational Biology

Protonation of Glutamate 208 Induces the Release of Agmatine in an Outward-facing Conformation of an Arginine/Agmatine Antiporter*
• Elia Zomot,
• Ivet Bahar
Published in issue: June 03, 2011
p19693-19701

Developmental Biology

Transcription Factor CCAAT Enhancer-binding Protein β (C/EBPβ) Regulates the Formation of a Unique Extracellular Matrix That Controls Uterine Stromal Differentiation and Embryo Implantation*
• Cyril Ramathal,
• Wei Wang,
• Elizabeth Hunt,
• Indrani C. Bagchi,
• Milan K. Bagchi
Published in issue: June 03, 2011
p19860-19871

DNA and Chromosomes

Tethering DNA Damage Checkpoint Mediator Proteins Topoisomerase IIβ-binding Protein 1 (TopBP1) and Claspin to DNA Activates Ataxia-Telangiectasia Mutated and RAD3-related (ATR) Phosphorylation of Checkpoint Kinase 1 (Chk1)*
• Laura A. Lindsey-Boltz,
• Aziz Sancar
Published in issue: June 03, 2011
p19229-19236

The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by Bulky Adduct-containing DNA*
• Michael G. Kemp,
• Laura A. Lindsey-Boltz,
• Aziz Sancar
Published in issue: June 03, 2011
p19237-19246

Enzymology

Kinetics of Activated Thrombin-activatable Fibrinolysis Inhibitor (TAFIa)-catalyzed Cleavage of C-terminal Lysine Residues of Fibrin Degradation Products and Removal of Plasminogen-binding Sites*
• Jonathan H. Foley,
• Paul F. Cook,
• Michael E. Nesheim
Published in issue: June 03, 2011
p19280-19286

5′-Methylthioadenosine Nucleosidase Is Implicated in Playing a Key Role in a Modified Futalosine Pathway for Menaquinone Biosynthesis in Campylobacter jejuni*
• Xu Li,
• Dmitry Apel,
• Erin C. Gaynor,
• Martin E. Tanner
Published in issue: June 03, 2011
p19392-19398

Molybdenum Nitrogenase Catalyzes the Reduction and Coupling of CO to Form Hydrocarbons*^♦
• Zhi-Yong Yang,
• Dennis R. Dean,
• Lance C. Seefeldt
Published in issue: June 03, 2011
p19417-19421

New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases*
• Rakesh K. Sit,
• Zoran Radić,
• Valeria Gerardi,
• ...
• Valery V. Fokin,
• K. Barry Sharpless,
• Palmer Taylor
Published in issue: June 03, 2011
p19422-19430

The Structure of a High Fidelity DNA Polymerase Bound to a Mismatched Nucleotide Reveals an “Ajar” Intermediate Conformation in the Nucleotide Selection Mechanism*
• Eugene Y. Wu,
• Lorena S. Beese
Published in issue: June 03, 2011
p19758-19767

Gene Regulation

Serine/Threonine Kinase 17A Is a Novel p53 Target Gene and Modulator of Cisplatin Toxicity and Reactive Oxygen Species in Testicular Cancer Cells*
• Pingping Mao,
• Mary P. Hever,
• Lynne M. Niemaszyk,
• ...
• Joanna S. Kerley-Hamilton,
• Sarah J. Freemantle,
• Michael J. Spinella
Published in issue: June 03, 2011
p19381-19391

Genistein Stimulates MCF-7 Breast Cancer Cell Growth by Inducing Acid Ceramidase (ASAH1) Gene Expression*
• Natasha C. Lucki,
• Marion B. Sewer
Published in issue: June 03, 2011
p19399-19409

MicroRNA-378 Targets the Myogenic Repressor MyoR during Myoblast Differentiation*
• Jeffrey Gagan,
• Bijan K. Dey,
• Ryan Layer,
• Zhen Yan,
• Anindya Dutta
Published in issue: June 03, 2011
p19431-19438

Thrombomodulin Is Silenced in Malignant Mesothelioma by a Poly(ADP-ribose) Polymerase-1-mediated Epigenetic Mechanism*
• Linda Nocchi,
• Marco Tomasetti,
• Monica Amati,
• Jiri Neuzil,
• Lory Santarelli,
• Franca Saccucci
Published in issue: June 03, 2011
p19478-19488

Intestinal Hypoxia-inducible Factor-2α (HIF-2α) Is Critical for Efficient Erythropoiesis*
• Erik R. Anderson,
• Xiang Xue,
• Yatrik M. Shah
Published in issue: June 03, 2011
p19533-19540

Transcriptional Regulation of Pro-apoptotic Protein Kinase Cδ
IMPLICATIONS FOR OXIDATIVE STRESS-INDUCED NEURONAL CELL DEATH *
• Huajun Jin,
• Arthi Kanthasamy,
• Vellareddy Anantharam,
• Ajay Rana,
• Anumantha G. Kanthasamy
Published in issue: June 03, 2011
p19840-19859

Glycobiology and Extracellular Matrices

Differential Use of Chondroitin Sulfate to Regulate Hyaluronan Binding by Receptor CD44 in Inflammatory and Interleukin 4-activated Macrophages*
• Brian Ruffell,
• Grace F.T. Poon,
• Sally S.M. Lee,
• ...
• Sie-Lung Tjew,
• Jessie Cooper,
• Pauline Johnson
Published in issue: June 03, 2011
p19179-19190

Highly Sulfated Nonreducing End-derived Heparan Sulfate Domains Bind Fibroblast Growth Factor-2 with High Affinity and Are Enriched in Biologically Active Fractions*
• Hicham Naimy,
• Jo Ann Buczek-Thomas,
• Matthew A. Nugent,
• Nancy Leymarie,
• Joseph Zaia
Published in issue: June 03, 2011
p19311-19319

High Mannose-binding Lectin with Preference for the Cluster of α1–2-Mannose from the Green Alga Boodlea coacta Is a Potent Entry Inhibitor of HIV-1 and Influenza Viruses*
• Yuichiro Sato,
• Makoto Hirayama,
• Kinjiro Morimoto,
• Naoki Yamamoto,
• Satomi Okuyama,
• Kanji Hori
Published in issue: June 03, 2011
p19446-19458

The Human Hyaluronan Synthase 2 (HAS2) Gene and Its Natural Antisense RNA Exhibit Coordinated Expression in the Renal Proximal Tubular Epithelial Cell^♦
• Daryn R. Michael,
• Aled O. Phillips,
• Aleksandra Krupa,
• ...
• Jason Webber,
• Min-young Kim,
• Timothy Bowen
Published in issue: June 03, 2011
p19523-19532

The Dominating Role of N-Deacetylase/N-Sulfotransferase 1 in Forming Domain Structures in Heparan Sulfate*
• Juzheng Sheng,
• Renpeng Liu,
• Yongmei Xu,
• Jian Liu
Published in issue: June 03, 2011
p19768-19776

A Systems Biology Approach for the Investigation of the Heparin/Heparan Sulfate Interactome*
• Alessandro Ori,
• Mark C. Wilkinson,
• David G. Fernig
Published in issue: June 03, 2011
p19892-19904

Immunology

Cooperation of Adenosine with Macrophage Toll-4 Receptor Agonists Leads to Increased Glycolytic Flux through the Enhanced Expression of PFKFB3 Gene*
• Almudena Ruiz-García,
• Eva Monsalve,
• Laura Novellasdemunt,
• ...
• Jorge Laborda,
• Ramón Bartrons,
• María José M. Díaz-Guerra
Published in issue: June 03, 2011
p19247-19258

PRR7 Is a Transmembrane Adaptor Protein Expressed in Activated T Cells Involved in Regulation of T Cell Receptor Signaling and Apoptosis*
• Matouš Hrdinka,
• Peter Dráber,
• Ondřej Štěpánek,
• ...
• Jan Pačes,
• Václav Hořejší,
• Karel Drbal
Published in issue: June 03, 2011
p19617-19629

Identification of Constitutively Active Interleukin 33 (IL-33) Splice Variant*
• Jaewoo Hong,
• Suyoung Bae,
• Hyunjhung Jhun,
• ...
• Eunsom Kim,
• Seunghyun Jo,
• Soohyun Kim
Published in issue: June 03, 2011
p20078-20086

Lipids

Lipid Peroxidation Modification of Protein Generates N^ϵ-(4-Oxononanoyl)lysine as a Pro-inflammatory Ligand*
• Takahiro Shibata,
• Yuuki Shimozu,
• Chika Wakita,
• ...
• Xiaochun Zhu,
• Lawrence M. Sayre,
• Koji Uchida
Published in issue: June 03, 2011
p19943-19957

Membrane Biology

Regulation of the Epithelial Na⁺ Channel by the RH Domain of G Protein-coupled Receptor Kinase, GRK2, and Gαq/11*
• Il-Ha Lee,
• Sung-Hee Song,
• Craig R. Campbell,
• Sharad Kumar,
• David I. Cook,
• Anuwat Dinudom
Published in issue: June 03, 2011
p19259-19269

cAMP Activates TRPC6 Channels via the Phosphatidylinositol 3-Kinase (PI3K)-Protein Kinase B (PKB)-Mitogen-activated Protein Kinase Kinase (MEK)-ERK1/2 Signaling Pathway*
• Bing Shen,
• Hiu-Yee Kwan,
• Xin Ma,
• ...
• Juan Du,
• Yu Huang,
• Xiaoqiang Yao
Published in issue: June 03, 2011
p19439-19445

Liver X Receptor β (LXRβ) Interacts Directly with ATP-binding Cassette A1 (ABCA1) to Promote High Density Lipoprotein Formation during Acute Cholesterol Accumulation*
• Masako Hozoji-Inada,
• Youichi Munehira,
• Kohjiro Nagao,
• Noriyuki Kioka,
• Kazumitsu Ueda
Published in issue: June 03, 2011
p20117-20124

Metabolism

Separation of Fast from Slow Anabolism by Site-specific PEGylation of Insulin-like Growth Factor I (IGF-I)*
• Friedrich Metzger,
• Waseem Sajid,
• Stefanie Saenger,
• ...
• Andreas Hoeflich,
• Pierre De Meyts,
• Hans-Joachim Schoenfeld
Published in issue: June 03, 2011
p19501-19510

Assessing the Role of the Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1) Three-finger Domain in Binding Lipoprotein Lipase*
• Anne P. Beigneux,
• Brandon S.J. Davies,
• Shelly Tat,
• ...
• Clive R. Pullinger,
• Loren G. Fong,
• Stephen G. Young
Published in issue: June 03, 2011
p19735-19743

Synergistic Interactions between Heregulin and Peroxisome Proliferator-activated Receptor-γ (PPARγ) Agonist in Breast Cancer Cells*
• Bae-Hang Park,
• Sean-Bong Lee,
• Donna B. Stolz,
• Yong J. Lee,
• Byeong-Chel Lee
Published in issue: June 03, 2011
p20087-20099

Microbiology

HIV-1 p17 Matrix Protein Interacts with Heparan Sulfate Side Chain of CD44v3, Syndecan-2, and Syndecan-4 Proteoglycans Expressed on Human Activated CD4⁺ T Cells Affecting Tumor Necrosis Factor α and Interleukin 2 Production*
• Maria A. De Francesco,
• Manuela Baronio,
• Claudio Poiesi
Published in issue: June 03, 2011
p19541-19548

Crystal Structure of Clostridium perfringens Enterotoxin Displays Features of β-Pore-forming Toxins*
• Kengo Kitadokoro,
• Kousuke Nishimura,
• Shigeki Kamitani,
• ...
• Shigeki Yamamoto,
• Hajime Karatani,
• Yasuhiko Horiguchi
Published in issue: June 03, 2011
p19549-19555

CgCYN1, a Plasma Membrane Cystine-specific Transporter of Candida glabrata with Orthologues Prevalent among Pathogenic Yeast and Fungi*
• Amit Kumar Yadav,
• Anand Kumar Bachhawat
Published in issue: June 03, 2011
p19714-19723

Active Participation of Cellular Chaperone Hsp90 in Regulating the Function of Rotavirus Nonstructural Protein 3 (NSP3)*
• Dipanjan Dutta,
• Shiladitya Chattopadhyay,
• Parikshit Bagchi,
• ...
• Nobumichi Kobayashi,
• Koki Taniguchi,
• Mamta Chawla-Sarkar
Published in issue: June 03, 2011
p20065-20077

Molecular Bases of Disease

Identification of a Novel Bcl-2-interacting Mediator of Cell Death (Bim) E3 Ligase, Tripartite Motif-containing Protein 2 (TRIM2), and Its Role in Rapid Ischemic Tolerance-induced Neuroprotection*
• Simon Thompson,
• Andrea N. Pearson,
• Michelle D. Ashley,
• ...
• Kate T. Morris,
• Roger P. Simon,
• Robert Meller
Published in issue: June 03, 2011
p19331-19339

Bone Overgrowth-associated Mutations in the LRP4 Gene Impair Sclerostin Facilitator Function*
• Olivier Leupin,
• Elke Piters,
• Christine Halleux,
• ...
• Andreas Bauer,
• Wim Van Hul,
• Michaela Kneissel
Published in issue: June 03, 2011
p19489-19500

Metabolomics Reveals Attenuation of the SLC6A20 Kidney Transporter in Nonhuman Primate and Mouse Models of Type 2 Diabetes Mellitus*
• Andrew D. Patterson,
• Jessica A. Bonzo,
• Fei Li,
• ...
• Barbara C. Hansen,
• Jeffrey R. Idle,
• Frank J. Gonzalez
Published in issue: June 03, 2011
p19511-19522

Fibroblast Growth Factor Receptor 3 (FGFR3) Is a Strong Heat Shock Protein 90 (Hsp90) Client
IMPLICATIONS FOR THERAPEUTIC MANIPULATION *
• Melanie B. Laederich,
• Catherine R. Degnin,
• Gregory P. Lunstrum,
• Paul Holden,
• William A. Horton
Published in issue: June 03, 2011
p19597-19604

Secretoglobin 3A2 Suppresses Bleomycin-induced Pulmonary Fibrosis by Transforming Growth Factor β Signaling Down-regulation*
• Reiko Kurotani,
• Satoshi Okumura,
• Tsutomu Matsubara,
• ...
• Hiroyuki Abe,
• Jerrold M. Ward,
• Shioko Kimura
Published in issue: June 03, 2011
p19682-19692

Neurotoxic 43-kDa TAR DNA-binding Protein (TDP-43) Triggers Mitochondrion-dependent Programmed Cell Death in Yeast*
• Ralf J. Braun,
• Cornelia Sommer,
• Didac Carmona-Gutierrez,
• ...
• Julia Ring,
• Sabrina Büttner,
• Frank Madeo
Published in issue: June 03, 2011
p19958-19972

Identification of Staphylococcal Nuclease Domain-containing 1 (SND1) as a Metadherin-interacting Protein with Metastasis-promoting Functions*
• Mario Andres Blanco,
• Maša Alečković,
• Yuling Hua,
• ...
• Zhen Xu,
• Ileana M. Cristea,
• Yibin Kang
Published in issue: June 03, 2011
p19982-19992

Activation of Bone Morphogenetic Protein 4 Signaling Leads to Glomerulosclerosis That Mimics Diabetic Nephropathy*
• Tatsuya Tominaga,
• Hideharu Abe,
• Otoya Ueda,
• ...
• Naoshi Fukushima,
• Kou-ichi Jishage,
• Toshio Doi
Published in issue: June 03, 2011
p20109-20116

Molecular Biophysics

Removal of Covalent Heterogeneity Reveals Simple Folding Behavior for P4-P6 RNA*
• Max Greenfeld,
• Sergey V. Solomatin,
• Daniel Herschlag
Published in issue: June 03, 2011
p19872-19879

A Novel Current Pathway Parallel to the Central Pore in a Mutant Voltage-gated Potassium Channel*
• Sylvia Prütting,
• Stephan Grissmer
Published in issue: June 03, 2011
p20031-20042

Neurobiology

Scapinin-induced Inhibition of Axon Elongation Is Attenuated by Phosphorylation and Translocation to the Cytoplasm
• Hovik Farghaian,
• Yu Chen,
• Ada W.Y. Fu,
• ...
• Nancy Y. Ip,
• Ann M. Turnley,
• Adam R. Cole
Published in issue: June 03, 2011
p19724-19734

Cross-talk between P2X4 and γ-Aminobutyric Acid, Type A Receptors Determines Synaptic Efficacy at a Central Synapse*
• Young-Hwan Jo,
• Emmanuelle Donier,
• Audrey Martinez,
• Maurice Garret,
• Estelle Toulmé,
• Eric Boué-Grabot
Published in issue: June 03, 2011
p19993-20004

Plant Biology

A Novel Transcription Factor, ERD15 (Early Responsive to Dehydration 15), Connects Endoplasmic Reticulum Stress with an Osmotic Stress-induced Cell Death Signal*
• Murilo S. Alves,
• Pedro A.B. Reis,
• Silvana P. Dadalto,
• Jerusa A.Q.A. Faria,
• Elizabeth P.B. Fontes,
• Luciano G. Fietto
Published in issue: June 03, 2011
p20020-20030

Protein Structure and Folding

Escherichia coli Thioredoxin-like Protein YbbN Contains an Atypical Tetratricopeptide Repeat Motif and Is a Negative Regulator of GroEL*
• Jiusheng Lin,
• Mark A. Wilson
Published in issue: June 03, 2011
p19459-19469

Structural and Functional Characterization of Rv2966c Protein Reveals an RsmD-like Methyltransferase from Mycobacterium tuberculosis and the Role of Its N-terminal Domain in Target Recognition*
• Atul Kumar,
• Kashyap Saigal,
• Ketan Malhotra,
• Krishna Murari Sinha,
• Bhupesh Taneja
Published in issue: June 03, 2011
p19652-19661

Asparagine 175 of Connexin32 Is a Critical Residue for Docking and Forming Functional Heterotypic Gap Junction Channels with Connexin26*
• So Nakagawa,
• Xiang-Qun Gong,
• Shoji Maeda,
• ...
• Yuko Misumi,
• Tomitake Tsukihara,
• Donglin Bai
Published in issue: June 03, 2011
p19672-19681

Bacterial Tubulin Distinct Loop Sequences and Primitive Assembly Properties Support Its Origin from a Eukaryotic Tubulin Ancestor*
• Antonio J. Martin-Galiano,
• María A. Oliva,
• Laura Sanz,
• ...
• Hugo Yebenes,
• Jose M. Valpuesta,
• Jose M. Andreu
Published in issue: June 03, 2011
p19789-19803

Characterizing the N- and C-terminal Small Ubiquitin-like Modifier (SUMO)-interacting Motifs of the Scaffold Protein DAXX*
• Eric Escobar-Cabrera,
• Mark Okon,
• Desmond K.W. Lau,
• Christopher F. Dart,
• Alexandre M.J.J. Bonvin,
• Lawrence P. McIntosh
Published in issue: June 03, 2011
p19816-19829

Protein Synthesis and Degradation

Prefoldin Subunits Are Protected from Ubiquitin-Proteasome System-mediated Degradation by Forming Complex with Other Constituent Subunits*
• Makoto Miyazawa,
• Erika Tashiro,
• Hirotake Kitaura,
• ...
• Hiroo Suto,
• Sanae M.M. Iguchi-Ariga,
• Hiroyoshi Ariga
Published in issue: June 03, 2011
p19191-19203

Physical and Functional Interaction of the HECT Ubiquitin-protein Ligases E6AP and HERC2*
• Simone Kühnle,
• Ulrike Kogel,
• Sandra Glockzin,
• ...
• Aaron Ciechanover,
• Konstantin Matentzoglu,
• Martin Scheffner
Published in issue: June 03, 2011
p19410-19416

High Avidity Binding to DNA Protects Ubiquitylated Substrates from Proteasomal Degradation*
• Giuseppe Coppotelli,
• Nouman Mughal,
• Diego Marescotti,
• Maria G. Masucci
Published in issue: June 03, 2011
p19565-19575

Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane*^♦
• Saori R. Yoshii,
• Chieko Kishi,
• Naotada Ishihara,
• Noboru Mizushima
Published in issue: June 03, 2011
p19630-19640

RNA

Endonuclease Associations with Three Distinct Editosomes in Trypanosoma brucei*
• Jason Carnes,
• Carmen Zelaya Soares,
• Carey Wickham,
• Kenneth Stuart
Published in issue: June 03, 2011
p19320-19330

Queuosine Deficiency in Eukaryotes Compromises Tyrosine Production through Increased Tetrahydrobiopterin Oxidation*
• Tatsiana Rakovich,
• Coilin Boland,
• Ilana Bernstein,
• Vimbai M. Chikwana,
• Dirk Iwata-Reuyl,
• Vincent P. Kelly
Published in issue: June 03, 2011
p19354-19363

A Disease-associated Polymorphism Alters Splicing of the Human CD45 Phosphatase Gene by Disrupting Combinatorial Repression by Heterogeneous Nuclear Ribonucleoproteins (hnRNPs)*
• Laura B. Motta-Mena,
• Sarah A. Smith,
• Michael J. Mallory,
• Jason Jackson,
• Jiarong Wang,
• Kristen W. Lynch
Published in issue: June 03, 2011
p20043-20053

Signal Transduction

Structural and Functional Characterization of the Wnt Inhibitor APC Membrane Recruitment 1 (Amer1)*
• Kristina Tanneberger,
• Astrid S. Pfister,
• Vitezslav Kriz,
• Vitezslav Bryja,
• Alexandra Schambony,
• Jürgen Behrens
Published in issue: June 03, 2011
p19204-19214

Calcium Input Potentiates the Transforming Growth Factor (TGF)-β1-dependent Signaling to Promote the Export of Inorganic Pyrophosphate by Articular Chondrocyte*
• Frederic Cailotto,
• Pascal Reboul,
• Sylvie Sebillaud,
• Patrick Netter,
• Jean-Yves Jouzeau,
• Arnaud Bianchi
Published in issue: June 03, 2011
p19215-19228

Glucocorticoid-independent Repression of Tumor Necrosis Factor (TNF) α-stimulated Interleukin (IL)-6 Expression by the Glucocorticoid Receptor
A POTENTIAL MECHANISM FOR PROTECTION AGAINST AN EXCESSIVE INFLAMMATORY RESPONSE
• Nicolette J.D. Verhoog,
• Andrea Du Toit,
• Chanel Avenant,
• Janet P. Hapgood
Published in issue: June 03, 2011
p19297-19310

Delayed Phosphorylation of Classical Protein Kinase C (PKC) Substrates Requires PKC Internalization and Formation of the Pericentrion in a Phospholipase D (PLD)-dependent Manner*
• Mohamad A. El-Osta,
• Jola Idkowiak-Baldys,
• Yusuf A. Hannun
Published in issue: June 03, 2011
p19340-19353

Adenomatous Polyposis Coli Protein Associates with C/EBP β and Increases Bacillus anthracis Edema Toxin-stimulated Gene Expression in Macrophages*
• Jason L. Larabee,
• Salika M. Shakir,
• Logan Hightower,
• Jimmy D. Ballard
Published in issue: June 03, 2011
p19364-19372

A New Highly Efficient Substrate-trapping Mutant of Protein Tyrosine Phosphatase 1B (PTP1B) Reveals Full Autoactivation of the Insulin Receptor Precursor*
• Samira Boubekeur,
• Nicolas Boute,
• Patrick Pagesy,
• Vladimir Zilberfarb,
• Névéna Christeff,
• Tarik Issad
Published in issue: June 03, 2011
p19373-19380

A Conserved Residue in the Yeast Bem1p SH3 Domain Maintains the High Level of Binding Specificity Required for Function*
• Maryna Gorelik,
• Karen Stanger,
• Alan R. Davidson
Published in issue: June 03, 2011
p19470-19477

Heterotrimeric G_i Proteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration*
• Ariel H. Polizio,
• Pilar Chinchilla,
• Xiaole Chen,
• Sangbumn Kim,
• David R. Manning,
• Natalia A. Riobo
Published in issue: June 03, 2011
p19589-19596

The NLR Adaptor ASC/PYCARD Regulates DUSP10, Mitogen-activated Protein Kinase (MAPK), and Chemokine Induction Independent of the Inflammasome*
• Debra J. Taxman,
• Elizabeth A. Holley-Guthrie,
• Max Tze-Han Huang,
• ...
• Yu Lei,
• Denis Gris,
• Jenny Pan-Yun Ting
Published in issue: June 03, 2011
p19605-19616

The Biflavonoid Amentoflavone Inhibits Neovascularization Preventing the Activity of Proangiogenic Vascular Endothelial Growth Factors*
• Valeria Tarallo,
• Laura Lepore,
• Marcella Marcellini,
• ...
• Claudio Pisano,
• Nunziatina De Tommasi,
• Sandro De Falco
Published in issue: June 03, 2011
p19641-19651

Mislocalization of the E3 Ligase, β-Transducin Repeat-containing Protein 1 (β-TrCP1), in Glioblastoma Uncouples Negative Feedback between the Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase 1 (PHLPP1) and Akt*
• Noel A. Warfel,
• Matt Niederst,
• Michael W. Stevens,
• Paul M. Brennan,
• Margaret C. Frame,
• Alexandra C. Newton
Published in issue: June 03, 2011
p19777-19788

Functional Apical Large Conductance, Ca²⁺-activated, and Voltage-dependent K⁺ Channels Are Required for Maintenance of Airway Surface Liquid Volume*
• Dahis Manzanares,
• Carlos Gonzalez,
• Pedro Ivonnet,
• ...
• Gregory E. Conner,
• H. Peter Larsson,
• Matthias Salathe
Published in issue: June 03, 2011
p19830-19839

The β-Arrestin Pathway-selective Type 1A Angiotensin Receptor (AT_1A) Agonist [Sar¹,Ile⁴,Ile⁸]Angiotensin II Regulates a Robust G Protein-independent Signaling Network*
• Ryan T. Kendall,
• Erik G. Strungs,
• Saleh M. Rachidi,
• ...
• Deirdre K. Luttrell,
• Michael G. Janech,
• Louis M. Luttrell
Published in issue: June 03, 2011
p19880-19891

Ca²⁺-dependent Monomer and Dimer Formation Switches CAPRI Protein between Ras GTPase-activating Protein (GAP) and RapGAP Activities
• Yanfeng Dai,
• Simon A. Walker,
• Edwin de Vet,
• Simon Cook,
• Heidi C.E. Welch,
• Peter J. Lockyer
Published in issue: June 03, 2011
p19905-19916

Ric-8B Is a GTP-dependent G Protein α_s Guanine Nucleotide Exchange Factor*
• PuiYee Chan,
• Meital Gabay,
• Forrest A. Wright,
• Gregory G. Tall
Published in issue: June 03, 2011
p19932-19942

Myotubularin Regulates Akt-dependent Survival Signaling via Phosphatidylinositol 3-Phosphate*
• Gina L. Razidlo,
• Dawn Katafiasz,
• Gregory S. Taylor
Published in issue: June 03, 2011
p20005-20019

Endoplasmic Reticulum Ca²⁺ Release Modulates Endothelial Nitric-oxide Synthase via Extracellular Signal-regulated Kinase (ERK) 1/2-mediated Serine 635 Phosphorylation*
• Zhihong Xiao,
• Tingting Wang,
• Honghua Qin,
• Chao Huang,
• Youmei Feng,
• Yong Xia
Published in issue: June 03, 2011
p20100-20108