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March 18, 2011

Volume 286Issue 11p8709-9893, e99919
Open Access
On The Cover: Transmission electron micrograph of a mouse hepatocyte nucleus, overlaid with fluorescent immunostaining for glucose-6-phosphate dehydrogenase (G6PD) and NADPH oxidase-4 (NOX4). Hepatic nuclei contain G6PD that produces NADPH inside the nucleus. NOX4 in the inner nuclear membrane uses this NADPH to produce superoxide directionally into the intermembrane space of the nuclear envelope (pseudocolored red). For details see the article by Spencer et al., pages 8977–8987....
On The Cover: Transmission electron micrograph of a mouse hepatocyte nucleus, overlaid with fluorescent immunostaining for glucose-6-phosphate dehydrogenase (G6PD) and NADPH oxidase-4 (NOX4). Hepatic nuclei contain G6PD that produces NADPH inside the nucleus. NOX4 in the inner nuclear membrane uses this NADPH to produce superoxide directionally into the intermembrane space of the nuclear envelope (pseudocolored red). For details see the article by Spencer et al., pages 8977–8987.

Papers of the Week

Minireviews

Reports

Bioenergetics

Cell Biology

Developmental Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Genomics and Proteomics

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Protein Structure and Folding

Protein Synthesis and Degradation

RNA

Signal Transduction

Additions and Corrections

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