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April 20, 2012

Volume 287Issue 17p13508-14309
Open Access
On The Cover: Ascorbic acid (vitamin C) is required for the good health of many plants and animals. Its biosynthesis has not been described previously in unicellular green algae such as Chlamydomonas reinhardtii, illustrated here fused with a vitamin C-rich orange. When confronted with oxidants in the environment or situations that promote oxidative stress, the alga responds by up-regulating expression of VTC2 encoding the rate-limiting enzyme GDP-l-galactose phosphorylase and increasing intracellular ascorbate levels. For details see the article by Urzica et al., pages 14234–14245....
On The Cover: Ascorbic acid (vitamin C) is required for the good health of many plants and animals. Its biosynthesis has not been described previously in unicellular green algae such as Chlamydomonas reinhardtii, illustrated here fused with a vitamin C-rich orange. When confronted with oxidants in the environment or situations that promote oxidative stress, the alga responds by up-regulating expression of VTC2 encoding the rate-limiting enzyme GDP-l-galactose phosphorylase and increasing intracellular ascorbate levels. For details see the article by Urzica et al., pages 14234–14245.

Papers of the Week

Minireviews

Bioenergetics

Cell Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

Neurobiology

Plant Biology

Protein Structure and Folding

RNA

Signal Transduction

Additions and Corrections

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