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January 02, 2012

Volume 287Issue 1p1-804
Open Access
On The Cover: Modulation of GPR55 by cannabinoids. The lipid LPI (l-α-lysophosphatidylinositol) is an endogenous agonist of GPR55. The phytocannabinoids Δ9-THCV, CBDV, and CBGV are potent inhibitors of LPI; certain cannabinoids display both activation of GPR55 and inhibition of LPI-mediated phosphorylation of ERK1/2. The figure illustrates the chemical structure of Δ9-THC, the main psychoactive constituent of the plant Cannabis sativa, on top of the cannabis flower. The cover image was designed by Sharon Anavi-Goffer and Reut Cohen. For details see the article by Anavi-Goffer et al., pages 91–104....
On The Cover: Modulation of GPR55 by cannabinoids. The lipid LPI (l-α-lysophosphatidylinositol) is an endogenous agonist of GPR55. The phytocannabinoids Δ9-THCV, CBDV, and CBGV are potent inhibitors of LPI; certain cannabinoids display both activation of GPR55 and inhibition of LPI-mediated phosphorylation of ERK1/2. The figure illustrates the chemical structure of Δ9-THC, the main psychoactive constituent of the plant Cannabis sativa, on top of the cannabis flower. The cover image was designed by Sharon Anavi-Goffer and Reut Cohen. For details see the article by Anavi-Goffer et al., pages 91–104.

Papers of the Week

Minireviews

Reports

Cell Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Genomics and Proteomics

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Plant Biology

Protein Structure and Folding

Signal Transduction

Additions and Corrections

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