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November 25, 2005

Volume 280Issue 47p38889-39676
Open Access
The cover shows the x-ray crystallographic structure of coral 8R-lipoxygenase docked to the membrane bilayer. Calcium binds to loops found in the N-terminal β-barrel, orienting exposed aromatic residues for membrane insertion and promoting enzyme access to the membrane-embedded substrate arachidonic acid. We would like to acknowledge James M. Westbrooks (Purdue University) for his assistance in preparation of the figure. For details see the article by Oldham et al., pages 39545–39552....
The cover shows the x-ray crystallographic structure of coral 8R-lipoxygenase docked to the membrane bilayer. Calcium binds to loops found in the N-terminal β-barrel, orienting exposed aromatic residues for membrane insertion and promoting enzyme access to the membrane-embedded substrate arachidonic acid. We would like to acknowledge James M. Westbrooks (Purdue University) for his assistance in preparation of the figure. For details see the article by Oldham et al., pages 39545–39552.

Papers of the Week

Reflections

Classics

Accelerated Publications

DNA: Replication, Repair, and Recombination

Genes: Structure and Regulation

RNA: Structure, Metabolism, and Catalysis

Protein Synthesis, Post-Translation Modification, and Degradation

Protein Structure and Folding

Enzyme Catalysis and Regulation

Metabolism and Bioenergetics

Glycobiology and Extracellular Matrices

Lipids and Lipoproteins

Membrane Transport, Structure, Function, and Biogenesis

Molecular Basis of Cell and Developmental Biology

Mechanisms of Signal Transduction

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