July 16, 2010
Volume 285Issue 29p21903-22722
Open Access
On The Cover: Immunohistochemical staining of a pancreatic tissue section from a non-obese type
1 diabetic (NOD) mouse with moderate hyperglycemia (280 mg/dl). Cytokines secreted
by infiltrating lymphocytes induce mixed lineage kinase-3 (MLK3) in the endocrine
cells of the islet of Langerhans leading to cell death and replacement of endocrine
cells with infiltrate. For details see the article by Humphrey et al., pages 22426–22436....Show more
On The Cover: Immunohistochemical staining of a pancreatic tissue section from a non-obese type
1 diabetic (NOD) mouse with moderate hyperglycemia (280 mg/dl). Cytokines secreted
by infiltrating lymphocytes induce mixed lineage kinase-3 (MLK3) in the endocrine
cells of the islet of Langerhans leading to cell death and replacement of endocrine
cells with infiltrate. For details see the article by Humphrey et al., pages 22426–22436.
