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March 02, 2012

Volume 287Issue 10p6960-7833
Open Access
On The Cover: A hemerythrin-like domain within F-box and leucine-rich repeat protein 5 serves as a cellular iron sensor. This domain adopts a stable structure when bioavailable iron levels are high, in the process sequestering a degron. When cellular iron levels are low, a degron is revealed to promote FBXL5 degradation by the proteasome and subsequent stabilization of its targets including iron regulatory protein 2. For details see the article by Thompson et al., pages 7357–7365....
On The Cover: A hemerythrin-like domain within F-box and leucine-rich repeat protein 5 serves as a cellular iron sensor. This domain adopts a stable structure when bioavailable iron levels are high, in the process sequestering a degron. When cellular iron levels are low, a degron is revealed to promote FBXL5 degradation by the proteasome and subsequent stabilization of its targets including iron regulatory protein 2. For details see the article by Thompson et al., pages 7357–7365.

Papers of the Week

Minireviews

Reports

Bioenergetics

Cell Biology

Computational Biology

Developmental Biology

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Protein Structure and Folding

Protein Synthesis and Degradation

RNA

Signal Transduction

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