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November 09, 2012

Volume 287Issue 46p38408-39274
Open Access
On The Cover: The sensitivity of TALE DNA binding domains to DNA methylation can be overcome by using TALE repeat N* as a 5-methylated cytosine binding module. The cover is an artistic representation of a DNA molecule bearing 5-methylated cytosines (magenta spheres and methyl moieties in pink) bound to a TALE DNA binding domain containing TALE repeats N*. This image was generated by Johann Goutard, Julien Valton, and Rachel Macmaster using Photoshop, PYMOL, and FoldX softwares and the PDB ID 3UGM dataset. For details see the article by Valton et al., pages 38427–38432....
On The Cover: The sensitivity of TALE DNA binding domains to DNA methylation can be overcome by using TALE repeat N* as a 5-methylated cytosine binding module. The cover is an artistic representation of a DNA molecule bearing 5-methylated cytosines (magenta spheres and methyl moieties in pink) bound to a TALE DNA binding domain containing TALE repeats N*. This image was generated by Johann Goutard, Julien Valton, and Rachel Macmaster using Photoshop, PYMOL, and FoldX softwares and the PDB ID 3UGM dataset. For details see the article by Valton et al., pages 38427–38432.

Papers of the Week

Bioenergetics

Cell Biology

Developmental Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Protein Structure and Folding

Protein Synthesis and Degradation

Signal Transduction

Additions and Corrections

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