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September 14, 2012

Volume 287Issue 38p31618-32297
Open Access
On The Cover: High and low resolution structures of the skeletal muscle ryanodine receptor. The gray portion corresponds to a cryo-EM map of the intact protein, solved at 9.6Å resolution. A crystal structure of the N-terminal region, docked 4 times in the 4-fold symmetric protein, is shown by blue spheres. Amino acids that correspond to positions of disease mutations are indicated in red. For details see the article by Van Petegem, pages 31624–31632....
On The Cover: High and low resolution structures of the skeletal muscle ryanodine receptor. The gray portion corresponds to a cryo-EM map of the intact protein, solved at 9.6Å resolution. A crystal structure of the N-terminal region, docked 4 times in the 4-fold symmetric protein, is shown by blue spheres. Amino acids that correspond to positions of disease mutations are indicated in red. For details see the article by Van Petegem, pages 31624–31632.

Papers of the Week

Minireviews

Reports

Cell Biology

Computational Biology

Developmental Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Protein Structure and Folding

Signal Transduction

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