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September 07, 2012

Volume 287Issue 37p30885-31617
Open Access
On The Cover: The two cellular receptors for immunoglobulin E (IgE) allosterically compete for binding. CD23 (red) binding to IgE (blue) induces a conformation change that inhibits FcεRI (gray) binding. FcεRI binding to IgE also inhibits its interaction with CD23. This mutual inhibition prevents simultaneous engagement of the two receptors, preventing inappropriate mast cell activation in the absence of allergens. For details see the article by Borthakur et al., pages 31457–31461....
On The Cover: The two cellular receptors for immunoglobulin E (IgE) allosterically compete for binding. CD23 (red) binding to IgE (blue) induces a conformation change that inhibits FcεRI (gray) binding. FcεRI binding to IgE also inhibits its interaction with CD23. This mutual inhibition prevents simultaneous engagement of the two receptors, preventing inappropriate mast cell activation in the absence of allergens. For details see the article by Borthakur et al., pages 31457–31461.

Papers of the Week

Minireviews

Reports

Bioenergetics

Cell Biology

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Plant Biology

Protein Structure and Folding

Protein Synthesis and Degradation

Signal Transduction

Additions and Corrections

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