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April 12, 2013

Volume 288Issue 15p10188-10952
Open Access
On The Cover: Cancer cells (blue) secrete small extracellular vesicles, exosomes, to their microenvironmental cells, such as fibroblasts (orange), immune cells (green), and endothelial cells (red). nSMase2 can activate exosomal miRNA secretion, which promotes cancer cell metastatic initiation efficiency through the induction of angiogenesis in the tumor microenvironment. The cover design was done by Dr. Eiji Takaoki (META Corporation Japan). For details see the article by Kosaka et al., pages 10849–10859....
On The Cover: Cancer cells (blue) secrete small extracellular vesicles, exosomes, to their microenvironmental cells, such as fibroblasts (orange), immune cells (green), and endothelial cells (red). nSMase2 can activate exosomal miRNA secretion, which promotes cancer cell metastatic initiation efficiency through the induction of angiogenesis in the tumor microenvironment. The cover design was done by Dr. Eiji Takaoki (META Corporation Japan). For details see the article by Kosaka et al., pages 10849–10859.

Papers of the Week

Minireviews

Reports

Bioenergetics

Cell Biology

Developmental Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Genomics and Proteomics

Glycobiology and Extracellular Matrices

Immunology

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Protein Structure and Folding

Protein Synthesis and Degradation

Signal Transduction

Additions and Corrections

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