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December 23, 2011

Volume 286Issue 51p43589-44294, e99983
Open Access
On The Cover: The SAMHD1 HIV-1 restriction factor is a dGTP-regulated deoxynucleotide triphosphohydrolase. SAMHD1 cleaves deoxynucleoside triphosphates at the α-phosphate position generating the deoxynucleoside and triphosphate products, preventing HIV-1 replication in myeloid cells. The HIV-2 Vpx accessory protein targets SAMHD1 for degradation in a viral strategy to control cellular deoxynucleotide levels for efficient replication. HIV-1-infected human T lymphocyte courtesy of Louis S. Kucera (Wake Forest School of Medicine). For details see the article by Powell et al., pages 43596–43600....
On The Cover: The SAMHD1 HIV-1 restriction factor is a dGTP-regulated deoxynucleotide triphosphohydrolase. SAMHD1 cleaves deoxynucleoside triphosphates at the α-phosphate position generating the deoxynucleoside and triphosphate products, preventing HIV-1 replication in myeloid cells. The HIV-2 Vpx accessory protein targets SAMHD1 for degradation in a viral strategy to control cellular deoxynucleotide levels for efficient replication. HIV-1-infected human T lymphocyte courtesy of Louis S. Kucera (Wake Forest School of Medicine). For details see the article by Powell et al., pages 43596–43600.

Papers of the Week

Reports

Reflections

Cell Biology

Computational Biology

Developmental Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Protein Structure and Folding

Protein Synthesis and Degradation

RNA

Signal Transduction

Additions and Corrections

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